Evidence map›Paper›PMID 41661326›Full record

ArticleSurgery today2026

Impact of laparoscopic sleeve gastrectomy on gut and oral microbiota diversity, weight loss, and the metabolic outcomes.

Akira Umemura, Akira Sasaki, Daisuke Sasaki, Akiko Iizuka, Manabu Chiba, Keiko Aihara, Naoko Ubukata, Hideki Kumagai, Yota Tanahashi, Takafumi Iwasaki and 2 more

Abstract read
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In one paragraph

Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Akira UmemuraDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan. aumemura@iwate-med.ac.jp.ORCID http://orcid.org/0000-0003-4181-7159
Akira SasakiDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
Daisuke SasakiDivision of Periodontology, Department of Conservative Dentistry, Iwate Medical University School of Medicine, Yahaba, Japan.
Akiko IizukaDivision of Periodontology, Department of Conservative Dentistry, Iwate Medical University School of Medicine, Yahaba, Japan.
Manabu ChibaDivision of Periodontology, Department of Conservative Dentistry, Iwate Medical University School of Medicine, Yahaba, Japan.
Keiko AiharaDivision of Periodontology, Department of Conservative Dentistry, Iwate Medical University School of Medicine, Yahaba, Japan.
Naoko UbukataDepartment of Food and Nutrition, Iwate Medical University Hospital, Yahaba, Japan.
Hideki KumagaiDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
Yota TanahashiDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
Takafumi IwasakiDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
Taro AndoDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.
Hiroyuki NittaDepartment of Surgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMetabolic and bariatric surgery (MBS) alters the gut microbiota (GM). Changes in oral microbiota (OM) after MBS have not yet been thoroughly investigated. In this study, we evaluated the changes in GM and OM before and after laparoscopic sleeve gastrectomy (LSG) in patients with severe obesity and investigated the relationship between improvements in GM/OM, weight loss, and the metabolic effects.

methodsThirty-seven severely obese patients who underwent LSG were enrolled in this study. We retrieved samples from the feces and oral mucosa from baseline to 1-year after LSG. These samples were subjected to a 16 S rRNA metagenomic analysis using a next-generation sequencer. We evaluated the significant changes in GM/OM and compared the results with clinical outcomes.

resultsRegarding OM diversity, g_Actinomyces (p = 0.003), o_Rothia (p = 0.020), and g_Streptococcus (p = 0.004) increased. With regard to GM, g_Slackia (p = 0.039), g_Bacillus (p = 0.030), g_Roseburia (p = 0.027), and g_Faecalibacterium (P = 0.003) increased, the proportion of p_ Firmicutes increased, and p_Bacteroidetes decreased in both groups. Changes in g_Akkermansia did not contribute to GM/OM diversity. The weight loss and remission rates of type 2 diabetes were higher in patients with increased normal oral flora and a recovery of g_Faecalibacterium in GM.

conclusionsWe clarified that the LSG reconstructs GM/OM as weight loss and the metabolic effects are enhanced.

Indexed as

Bariatric SurgeryGastrectomyGastrointestinal MicrobiomeLaparoscopyMouthObesity, MorbidWeight LossAdultFemaleHumansMaleMiddle AgedTreatment OutcomeDiversityGut microbiotaLaparoscopic sleeve gastrectomyMetabolic dysfunction associated steatohepatitisMetabolic surgeryOral microbiotaType 2 diabetes

Identifiers

PMID41661326

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.