Integrative Analysis of Trace Elements, Oxidative Stress, and Psychological Distress in Epilepsy: Biochemical Profiling and In Silico Docking Insights.

Shani Vishwakarma, Abhishek Pathak, Anil Kumar Maurya, Surbhi Singh, Ashish Ashish, Nitish Kumar Singh, Royana Singh

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Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shani VishwakarmaDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Abhishek PathakDepartment of Neurology, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Anil Kumar MauryaDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Surbhi SinghDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Ashish AshishMultidisciplinary Research Unit, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Nitish Kumar SinghMultidisciplinary Research Unit, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Royana SinghDepartment of Anatomy, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. royanasingh@bhu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a complex neurological disorder shaped by oxidative stress, imbalances in trace elements, and psychological distress, yet the mechanisms linking these factors to seizure severity and psychiatric outcomes remain poorly understood. This study investigated their interplay through clinical, biochemical, and in silico approaches. A cross sectional analysis was conducted on 200 epilepsy patients and 200 controls with comparable age and sex distributions. Psychological distress was measured using the Depression Anxiety Stress Scale-21 (DASS-21). Serum levels of copper (Cu

Indexed as

EpilepsyOxidative StressStress, PsychologicalTrace ElementsAdultCopperCross-Sectional StudiesFemaleGlutathioneHumansMaleMalondialdehydeMolecular Docking SimulationSuperoxide DismutaseYoung AdultZincCopperGlutathioneMalondialdehydeSuperoxide DismutaseTrace ElementsZincBiomarkerEpilepsyMolecular dockingOxidative stressPsychological distressTrace elements

Identifiers

PMID41661398

DOI10.1186/s41983-022-00479-5

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.