ArticleGenes & genomics2026
Novel citrivirus and prunevirus genomes further demonstrate the recurrent, independent acquisition of nucleic acid-binding proteins in the family Betaflexiviridae.
Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
backgroundSome plant RNA viruses in the family Betaflexiviridae encode a nucleic acid-binding protein (NABP), which enhances viral infectivity. Until recently, Salvia divinorum RNA virus 1 (SdRV1) was the only known member of the genus Citrivirus to encode a NABP.
objectiveThis study aimed to identify novel Betaflexiviridae genomes encoding NABPs and to investigate their evolutionary origins through comparative and phylogenetic analysis.
methodsPublicly available plant transcriptome datasets were screened to identify Betaflexiviridae-like viral sequences. Twelve viral genome contigs corresponding to ten distinct viruses were assembled and annotated. Phylogenetic trees were constructed using replicase and NABP protein sequences.
resultsSix putative novel species were identified within the genera Citrivirus, Prunevirus, and a potential new genus. Aquilaria sinensis virus 1 (AquSiV1) encoded a NABP, making it the second known Citrivirus with a putative copy of this gene. Hippophae rhamnoides virus 1 (HipRhV1), which also encoded a NABP, formed a distinct lineage, possibly representing a novel genus. Phylogenetic analysis of NABPs revealed topologies incongruent with the replicase phylogeny, suggesting recurrent, independent acquisition events.
conclusionThese findings expand the known genomic and taxonomic diversity of the genera Citrivirus and Prunevirus, and support the hypothesis that NABP genes have been independently and repeatedly acquired within the family Betaflexiviridae.
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