Evidence map›Paper›PMID 41661667›Full record

ArticleeLife2026

In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Preat, Pierre-Yves Plaçais, Auguste Genovesio

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philémon RousselComputational Bioimaging and Bioinformatics, IBENS, École normale supérieure, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0009-0009-6377-2167
Mingyi ZhouEnergy & Memory, Brain Plasticity Unit, ESPCI, CNRS, Université PSL, Paris, France.ORCID https://orcid.org/0000-0002-4544-1489
Chiara StringariLaboratory for Optics and Biosciences, École Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, Palaiseau, France.ORCID https://orcid.org/0000-0002-0550-7463
Thomas PreatEnergy & Memory, Brain Plasticity Unit, ESPCI, CNRS, Université PSL, Paris, France.
Pierre-Yves PlaçaisEnergy & Memory, Brain Plasticity Unit, ESPCI, CNRS, Université PSL, Paris, France.ORCID https://orcid.org/0000-0001-8426-4465
Auguste GenovesioComputational Bioimaging and Bioinformatics, IBENS, École normale supérieure, CNRS, INSERM, Université PSL, Paris, France.ORCID https://orcid.org/0000-0003-1877-5595

Funding

Agence Nationale de la Recherche ANR-10-IDEX-0001-02 PSL*Agence Nationale de la Recherche ANR-10-INBS-04Agence Nationale de la Recherche ANR-10-LABX-54 MEMOLIFEAgence Nationale de la Recherche ANR-11-EQPX-0029Agence Nationale de la Recherche ANR-17-QLIFEEuropean Research Council ERC-AdG-741550Human Frontier Science Program RGY0078/2017 ChroMetRégion Ile-de-France DIM ELICIT
6 · The paper itself

Abstract

Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes NADH and NADPH (collectively referred to as NAD(P)H) offers the possibility to resolve cellular metabolic profiles with high spatial precision. However, NAD(P)H FLIM's capacity to detect subtle variations in neuronal metabolism has not been demonstrated. In this study, we applied NAD(P)H FLIM to map the metabolic profiles of

Indexed as

DrosophilaDrosophila melanogasterLearningMushroom BodiesNeuronsOptical ImagingAnimalsMemoryNADNADPNADNADPD. melanogasterFLIMmemorymetabolismneuroenergeticsneuroscienceregistration

Identifiers

PMID41661667
PMCPMC12885480

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.