Evidence map›Paper›PMID 41662497›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A LDH-Based Supramolecular Photosensitizer-Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration.

Tao Wang, Yixin Bian, Tingting Hu, Mengyang Li, Yuqin Tan, Yu Yang, Xiaolan Jian, Xisheng Weng, Chaoliang Tan, Ruizheng Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tao WangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, P. R. China.
Yixin BianDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, P. R. China.
Tingting HuDepartment of Electrical Engineering & Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P. R. China.
Mengyang LiState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, P. R. China.
Yuqin TanGraduate School, Hunan University of Chinese Medicine, Changsha, Hunan, P. R. China.
Yu YangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, P. R. China.
Xiaolan JianHunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha, Hunan, P. R. China.
Xisheng WengDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, P. R. China.
Chaoliang TanDepartment of Electrical Engineering & Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, P. R. China.ORCID https://orcid.org/0000-0003-1695-5285
Ruizheng LiangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, P. R. China.

Funding

Interdisciplinary Research Center of Beijing University of Chemical Technology XK2025-05National Key Research and Development Program of China 2024YFA1211600National Natural Science Foundation of China 81630064National Natural Science Foundation of China-Excellent Young Scientists Fund 52322317Shenzhen Basic Research General Program JCYJ20250604184523030Start-Up Grant of City University of Hong Kong 9610710
6 · The paper itself

Abstract

Layered double hydroxide (LDH)-based materials have been explored as efficient photosensitizers for photodynamic therapy (PDT) or functional agents for bone regeneration, holding great promise in the synergistic PDT-mediated osteosarcoma treatment and bone reconstruction. Herein, we report the functionalization of 5-iodoisophthalic acid (I-IPA)-intercalated MgZnAl-LDH onto bioactive glass scaffold (BGS) to construct a bifunctional composite scaffold (BGS/I-LDH) for integrated osteosarcoma treatment and bone regeneration. The surface functionalization of I-LDH onto BGS confers BGS/I-LDH high-efficiency reactive oxygen species generation performance under 1270 nm laser irradiation, resulting in a singlet oxygen quantum yield up to 1.53, which is significantly superior to that of previously reported NIR-excited PSs. Moreover, thanks to the sustained release of Mg

Indexed as

Bone NeoplasmsBone RegenerationGlassHydroxidesOsteosarcomaPhotosensitizing AgentsTissue ScaffoldsAnimalsHumansPhotochemotherapyHydroxidesPhotosensitizing Agentsbioactive glass scaffoldsbone regenerationlayered double hydroxidesosteosarcoma treatmentphotodynamic therapy

Identifiers

PMID41662497
PMCPMC13088352

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.