Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium.

Jia Du, Rui Deng, Ya Wu, Hong-Xia Ren, Zong-Hong Lin, Yang-Bao Miao

Abstract readReview

In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia DuDepartment of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chengdu, China.

Rui DengDepartment of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chengdu, China.

Ya WuDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Hong-Xia RenCollege of Light Industry and Engineering, Sichuan Technology & Business College, Chengdu, China.

Zong-Hong LinDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Yang-Bao MiaoDepartment of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0000-0001-7705-8567

Funding

15th Batch of Basic Research Funds for Central Universities and Colleges Frontier Cultivation Project ZYGX2024J026Jiangsu Hansoh Pharmaceutical Group Co., LtdNational Natural Science Foundation of China 32401173National Natural Science Foundation of China 82200432National Science and Technology Council (NSTC) of Taiwan 113-2628-E-002-010-MY3National Science and Technology Council (NSTC) of Taiwan 114-2314-B-002-131-MY3Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital 30420220004Sichuan Province Postdoctoral Special Funding Project TB2024005Sichuan Province Science and Technology Activities Funding for Returned Overseas Scholars, National Science and Technology Council (NSTC) of Taiwan under grant 113-2628-E-002-010-MY3Sichuan Province Science and Technology Activities Funding for Returned Overseas Scholars, National Science and Technology Council (NSTC) of Taiwan under grant 114-2314-B-002-131-MY3Sichuan Science and Technology Program 24GJHZ0072

6 · The paper itself

Abstract

The intricacies of neuroimmunity underscore its pivotal role in the onset and progression of neurological diseases, yet its precise modulation remains a formidable challenge. The emergence of nanogenerators offers a promising avenue to overcome these obstacles, introducing a new paradigm for regulating neural immune responses. This review delves into the complex physiological landscape of neuroimmunity, emphasizing its profound impact on overall health and disease outcomes. It systematically examines the mechanisms by which nanogenerators interact with and modulate neuroimmune processes, while also charting key developmental milestones, synthesis strategies, and classification frameworks of nanogenerators. Particular attention is given to the application of nanogenerators in neuroimmunomodulation, critically analyzing current achievements, persistent challenges, and future directions. Furthermore, the review highlights the potential clinical translation of nanogenerators, notably their capacity to stimulate the vagus nerve and activate the brain's immune system, offering innovative therapeutic strategies for a spectrum of neurological disorders, including epilepsy, PD, AD, and stroke. As we navigate the ethereal tightrope of immune homeostasis, nanogenerators emerge as beacons of hope, heralding a future in which precise, targeted modulation of neuroimmunity may evolve from conceptual possibility to clinical reality.

Indexed as

BrainNanotechnologyNervous System DiseasesNeuroimmunomodulationNeuronsVagus NerveAnimalsHumansnanogeneratorsneuroimmunomodulationneurological disease therapyself‐powered neuromodulationvagus nerve stimulation

Identifiers

PMID41662500

DOI10.1002/advs.202512284

PMCPMC12970229

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.