Evidence map›Paper›PMID 41663400›Full record

ArticleNature communications2026

Phytic acid (InsP

Sujan Chatterjee, Zachary Sin, Nguyen Tran, Loretta Vierra, Anuj Shukla, Tam Tran, George Koshkaryan, Kevin Ritter, Xue Bessie Su, Saharat Jolak Ragsac and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Phytic acid (InsPNature communications · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Sujan ChatterjeeNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.ORCID http://orcid.org/0009-0000-2281-9066
Zachary SinNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
Nguyen TranNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
Loretta VierraNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
Anuj ShuklaInstitute of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany.
Tam TranNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
George KoshkaryanNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
Kevin RitterInstitute of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany.
Xue Bessie SuMedical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK.
Saharat Jolak RagsacNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
Seungman ParkDepartment of Mechanical Engineering, University of Nevada, Las Vegas, Las Vegas, NV, USA.
Qian LiuNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.
Richard VanSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.ORCID http://orcid.org/0009-0006-7275-3441
Katherine HuangDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Kayci Huff-HardyDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Richard RoodDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Anas GremidaDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Martin GregoryDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Chien-Huan ChenDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Mira V HanSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.
Parakkal DeepakDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Adolfo SaiardiMedical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-4351-0081
Henning J JessenInstitute of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-1025-9484
Prasun GuhaNevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA. prasun.guha@unlv.edu.ORCID http://orcid.org/0000-0003-1224-7361

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Eduardo A Robleto · 2012 to 2026
$58.0M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8M
The Genome Analysis and Sequencing Pipeline (GASP)P20GM121325 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI CHEN, JINGCHUN · 2018 to 2022
$11.5M
NIDDK NIH HHS P30 DK052574NIGMS NIH HHS P20 GM103440NIGMS NIH HHS P20 GM121325
6 · The paper itself

Abstract

HDAC inhibition shows promise in cancer treatment but pan-HDAC inhibitors cause gastrointestinal issues in 48% of patients. Understanding HDAC activation mechanisms is crucial to treating diverse diseases beyond cancer. Our study reveals that inositol polyphosphate multikinase (IPMK) and inositol hexakisphosphate (InsP

Indexed as

Epigenesis, GeneticHistone DeacetylasesIntestinal Barrier FunctionPhytic AcidAcetylationAnimalsHistone Deacetylase 3HistonesHumansIntestinal MucosaMicePermeabilityPhosphotransferases (Alcohol Group Acceptor)Histone Deacetylase 3Histone DeacetylasesHistonesinositol polyphosphate multikinasePhosphotransferases (Alcohol Group Acceptor)Phytic Acid

Identifiers

PMID41663400
PMCPMC13219500

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.