Purification and characterization of a dihydroxy Oxocyclohexyl acetate derivative from endophytic Aspergillus Candidus targeting Candida albicans lanosterol 14α-Demethylase.

Ayesha Saleem, Saeed Ullah Khattak, Sajjad Ahmad, Awais Ahmad, Hatoon S Alsagri, Alaa Menshawi

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Structure-Guided Design of an Interface-Derived Inhibitor Peptide Against Spodoptera frugiperda Digestive Trypsins.Archives of insect biochemistry and physiology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayesha SaleemCentre of Biotechnology and Microbiology (COBAM), University of Peshawar, Peshawar, KPK, Pakistan.

Saeed Ullah KhattakCentre of Biotechnology and Microbiology (COBAM), University of Peshawar, Peshawar, KPK, Pakistan.

Sajjad AhmadDepartment of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan.

Awais AhmadInformation Systems Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia. abmohmmed@imamu.edu.sa.

Hatoon S AlsagriInformation Systems Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Alaa MenshawiInformation Systems Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Funding

Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) IMSIU-DDRSP2502

6 · The paper itself

Abstract

Endophytic fungi are important sources of structurally diverse natural products with potential antifungal activity. In this study, four endophytic fungi were isolated from Rosmarinus officinalis and screened for bioactivity. An isolate identified as Aspergillus candidus was selected based on its antifungal profile, and its secondary metabolites were investigated. Cultivation in modified Czapek Yeast Broth followed by silica gel chromatography yielded a single major metabolite. Comprehensive GC-MS, FTIR, and 1D/2D NMR analysis established its structure as (2E, 7E)-6, 9-dihydroxy-10-(3-hydroxy-5-oxocyclohexyl) deca-2, 7-dien-1-yl acetate (C

Indexed as

14-alpha Demethylase InhibitorsAcetatesAntifungal AgentsAspergillusCandida albicansFungal ProteinsSterol 14-DemethylaseCytochrome P-450 Enzyme SystemEndophytesMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationRosmarinus14-alpha Demethylase InhibitorsAcetatesAntifungal Agentscytochrome P-450 CYP51, Candida albicansCytochrome P-450 Enzyme SystemFungal ProteinsSterol 14-DemethylaseFTIRGCMSMolecular docking simulationNatural product discoveryNMRRosmarinus officinalis

Identifiers

PMID41663451

DOI10.1038/s41598-025-31974-3

PMCPMC12886800

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.