Evidence map›Paper›PMID 41663552›Full record

ReviewJournal of neurology2026

Cerebellar clinical syndromes: the triad and rating scales.

Mario Manto, Hiroshi Mitoma, Anna L Burt, Jeremy D Schmahmann

Abstract readReview
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In one paragraph

Review in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mario MantoUnité des Ataxies Cérébelleuses, CHU-Charleroi, Charleroi, Belgium. mario.manto@ulb.be.ORCID http://orcid.org/0000-0001-6034-4380
Hiroshi MitomaDepartment of Medical Education, Tokyo Medical University, Tokyo, Japan.
Anna L BurtAtaxia Center, Division of Behavioral Neurology, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Jeremy D SchmahmannAtaxia Center, Division of Behavioral Neurology, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Funding

Japan Society for the Promotion of Science London 24K02668
6 · The paper itself

Abstract

The last four decades have led to a clarification of the clinical deficits exhibited by cerebellar patients and a set of reliable and valid clinical ataxia rating scales are now available for both the assessment and follow-up of cerebellar ataxias. Cerebellar syndrome is now divided into three principal categories: the cerebellar motor syndrome (CMS), the vestibulo-cerebellar syndrome (VCS), and the cerebellar cognitive affective syndrome/ Schmahmann syndrome (CCAS/SS). CMS corresponds to motor impairments, including dysmetria, kinetic tremor, asynergia, dysdiadochokinesia, and dyschronometria. VCS includes oculomotor disturbances, such as saccadic dysmetria, jerky pursuit, downbeat nystagmus, and gaze-evoked nystagmus. CCAS/SS includes a spectrum of cognitive and affective deficits targeting executive functions, spatial cognition, language processing, and emotional regulation. The International Cooperative Ataxia Rating Scale (ICARS) was developed as an objective quantitative measure of cerebellar ataxias and assesses CMS and VCS, while the more streamlined Scale for the Assessment and Rating of Ataxia (SARA) was introduced specifically for the evaluation of motor deficits corresponding to the CMS. The Brief Ataxia Rating Scale (BARS) has also been proposed as a concise yet effective alternative, demonstrating enhanced efficiency and significant correlations with established cerebellar syndrome subtypes CMS/VCS. Furthermore, the Scale for Oculomotor Disorders in Ataxia (SODA) assesses the VCS, and the CCAS/Schmahmann Scale (CCAS-SS) and the Cerebellar Neuropsychiatric Rating Scale (CNRS and CNRS-2) assess the cognitive and emotional impairments in the CCAS/SS. Together with the Patient-Reported Outcome Measure of Ataxia (PROM-Ataxia) that covers all of these domains, the recognition of the three types of cerebellar syndrome and the application of validated clinician-administered and patient-completed rating scales represent a key step forward in the practice of ataxiology and training of students.

Indexed as

Cerebellar DiseasesSeverity of Illness IndexCerebellar AtaxiaCerebellar Cognitive Affective SyndromeHumansAtaxiaBARSCCAS-SCerebellar cognitive affective or Schmahmann syndrome (CCAS/SS)CerebellumCNRSCNRS-2ICARS SARAPROM-AtaxiaSODA

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.