Evidence map›Paper›PMID 41663647›Full record

ArticleScientific reports2026

Time stability of Intensive Care Infection Score (ICIS) as a cellular hematology biomarker for infection in critically ill patients.

Noelle Nacke, Mascha Zuther, Christian Hönemann, Mathias Zimmermann, Bastian Blömer, Stefanie Klatte, Jens-Christian Schewe, Marie-Luise Rübsam

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noelle NackeDepartment of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital Münster, Münster, Germany.
Mascha ZutherDepartment of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital Münster, Münster, Germany.
Christian HönemannDepartment of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital Münster, Münster, Germany.
Mathias ZimmermannMSH Medical School Hamburg, University of Applied Sciences and Medical University, Hamburg, Germany.
Bastian BlömerDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre Rostock, Rostock, Germany.
Stefanie KlatteMedical Affairs Department, Sysmex Europe SE, Hamburg, Germany.
Jens-Christian ScheweDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre Rostock, Rostock, Germany.
Marie-Luise RübsamDepartment of Anesthesia and Operative Intensive Care Medicine, St. Marienhospital Vechta, Marienstraße 6-8, 49377, Vechta, Germany. marie-luise.ruebsam@kh-vec.de.ORCID http://orcid.org/0000-0001-6678-7297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Intensive Care Infection Score (ICIS) is composed of blood-cell derived parameters to discriminate infection or sepsis from non-infectious inflammatory responses. The study examines the stability of the complete blood count (CBC) and ICIS after blood sample storage at room temperature (RT) and determines the impact of potential variations on ICIS and its clinical interpretation. In total, 53 K3-EDTA-blood samples collected from critically ill patients were analyzed at baseline (t0) and after 8 h (t1) on a hematology analyzer. After a mean storage time of 514 min at RT, all ICIS parameters in the CBC are stable. Observed transitions of ICIS classification were neither statistically (p = 0.082) nor clinically relevant as no sample was classified as falsely positive or falsely negative. This study demonstrates the stability of the ICIS in K3-EDTA whole blood for up to 8 h at RT, preserving its clinical interpretation and utility in distinguishing infection from non-infectious inflammatory responses, even if analysis is delayed.

Indexed as

BiomarkersCritical CareCritical IllnessSepsisAgedBlood Cell CountFemaleHumansMaleMiddle AgedTime FactorsBiomarkersComplete blood countCritically ill patientFluorescence flow cytometryInfection biomarkerIntensive Care Infection ScoreSepsis biomarkerStability

Identifiers

PMID41663647
PMCPMC12891660

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.