Evidence map›Paper›PMID 41663680›Full record

ArticleScientific reports2026

EEG-based predictors of motor recovery during immersive VR-BCI rehabilitation.

Madalena Valente, Diogo Branco, Sergi Bermúdez I Badia, Jean-Claude Fernandes, Patrícia Figueiredo, Athanasios Vourvopoulos

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madalena ValenteBioengineering Department, Institute for Systems and Robotics - Lisboa, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Diogo BrancoFaculty of Exact Sciences and Engineering & NOVA LINCS, University of Madeira, Funchal, Portugal.
Sergi Bermúdez I BadiaFaculty of Exact Sciences and Engineering & NOVA LINCS, University of Madeira, Funchal, Portugal.
Jean-Claude FernandesBioengineering Department, Institute for Systems and Robotics - Lisboa, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Patrícia FigueiredoBioengineering Department, Institute for Systems and Robotics - Lisboa, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Athanasios VourvopoulosBioengineering Department, Institute for Systems and Robotics - Lisboa, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal. athanasios.vourvopoulos@tecnico.ulisboa.pt.

Funding

Fundação para a Ciência e a Tecnologia 10.54499/2022.02283.PTDC
6 · The paper itself

Abstract

Motor impairment following stroke frequently leads to long-term disability, limiting independence and quality of life. Brain-Computer Interface (BCI) systems integrating motor imagery (MI) with virtual reality (VR) offer promising avenues for enhancing neuroplasticity and engagement through immersive, real-time, and proprioceptive feedback. Yet, identifying reliable electroencephalography (EEG)-based biomarkers that reflect or predict recovery remains challenging. This study investigated the relationship between event-related desynchronization (ERD) dynamics during MI-VR training and motor recovery in individuals with chronic stroke. Fourteen participants with stroke (9 experimental, 5 control) completed a 4-week VR-BCI intervention and were compared with a non-stroke reference cohort (N = 35). Linear mixed-effects models assessed ERD modulation across sessions and groups, and a two-stage regression evaluated the predictive value of ERD features for Fugl-Meyer Assessment (FMA) gains. Results showed no significant ERD change across sessions, but stroke participants exhibited significantly reduced ERD compared to controls. Baseline ERD amplitude predicted motor improvement, whereas ERD progression did not. Ipsilateral ERD showed a compensatory trend in ischemic stroke. These findings indicate that baseline ERD may serve as a stronger prognostic biomarker than short-term ERD dynamics, supporting the development of personalized VR-BCI rehabilitation strategies for chronic stroke recovery.

Indexed as

Brain-Computer InterfacesElectroencephalographyRecovery of FunctionStrokeStroke RehabilitationVirtual RealityAgedFemaleHumansMaleMiddle AgedBrain-Computer InterfacesEvent-Related DesynchronizationMotor ImageryStroke RehabilitationVirtual Reality

Identifiers

PMID41663680
PMCPMC12953618

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.