Evidence map›Paper›PMID 41663874›Full record

ArticleMolecular nutrition & food research2026

Preventive Effect of Powder Bergamot Juice (Citrus bergamia Risso & Poiteau) on Pathophysiological Processes of Renal Disease in an Experimental Western Diet Model.

Marina de Paula Salomé Dos Santos, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Taynara Aparecida Vieira, Núbia Alves Grandini, Thiago Luiz Novaga Palacio, Luís Eduardo Sormani, Caíque Manentti Caccia, Jordanna Cruzeiro, Fabiane Valentini Francisqueti-Ferron and 1 more

Abstract read
In one paragraph

Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marina de Paula Salomé Dos SantosBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Juliana Silva SiqueiraBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Erika Tiemi Nakandakare-MaiaBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Taynara Aparecida VieiraBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Núbia Alves GrandiniBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Thiago Luiz Novaga PalacioBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Luís Eduardo SormaniBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Caíque Manentti CacciaBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Jordanna CruzeiroBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Fabiane Valentini Francisqueti-FerronBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.
Camila Renata CorrêaBotucatu Medical School, São Paulo State University (Unesp), Botucatu, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (306640/2023-6)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.899588/2023-00)FAPESPFundação de Amparo à Pesquisa do Estado de São Paulo (2021/13050-2)
6 · The paper itself

Abstract

The Western diet (WD), rich in sugars and saturated fats, is linked to metabolic disturbances that contribute to chronic kidney disease (CKD). Natural antioxidants have been investigated in several diseases, including bergamot (Citrus bergamia), a citrus fruit rich in polyphenols with recognized antioxidant and anti-inflammatory properties. This study evaluated the preventive effect of powder bergamot juice (PBJ) on renal alterations induced by WD in male Wistar rats. Animals were allocated into four groups (n = 7): control diet, control + PBJ (250 mg/kg), WD; and WD + PBJ for 20 weeks. WD groups also received 25% sucrose in drinking water. Nutritional, metabolic, hormonal, renal, and oxidative stress (OS) markers were measured. Statistical analyses included two-way ANOVA/Tukey's post-hoc and Kruskal-Wallis/Dunn's post-hoc (p < 0.05). WD increased caloric intake, body weight, adiposity index, glucose, triglycerides, and renal OS markers, and reduced kidney function. PBJ supplementation reduced adiposity and triglycerides, improved antioxidant enzyme activity, and preserved renal function. PBJ attenuated metabolic and oxidative alterations induced by WD, supporting its potential as a preventive strategy against early renal dysfunction associated with CKD.

Indexed as

AntioxidantsCitrusDiet, WesternKidney DiseasesPolyphenolsAnimalsDisease Models, AnimalFruit and Vegetable JuicesKidneyMaleOxidative StressPowdersRatsRats, WistarAntioxidantsPolyphenolsPowdersflavonoidskidney diseaseobesityredox imbalance

Identifiers

PMID41663874
PMCPMC12886603

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.