SynthesisBMC cardiovascular disorders2026
Metabolic alterations associated with sacubitril/valsartan treatment: a systematic review and meta-analysis.
Synthesis in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor, influences metabolic pathways, potentially altering glycemic indices and lipid profiles, but evidence remains scattered. Therefore, we aimed to quantify changes in glycemic indices, lipid profiles, and uric acid with sacubitril/valsartan.
methodsThis study followed PRISMA guidelines and was registered on PROSPERO. We searched PubMed, Scopus, and Web of Science for studies reporting within-group changes in metabolic parameters in adults receiving sacubitril/valsartan. Risk of bias was separately assessed for randomized clinical trials (RCTs) and non-RCTs. Whenever multiple populations from a single record were included in an outcome, a multilevel meta-analysis was used; otherwise, a conventional random-effects meta-analysis was applied.
resultsTwenty-seven studies were included, involving a total of 11,093 participants. Meta-analysis showed significant reduction in hemoglobin A1c (MD -0.47%; 95% confidence interval [CI] -0.75 to - 0.20), fasting blood glucose (MD -11.94 mg/dL; 95% CI -23.63 to -0.25), lowdensity lipoprotein (MD -12.1 mg/dL; 95% CI - 20.37 to -3.82), triglycerides (MD -21.95 mg/dL; 95% CI -40.02 to -3.88), total cholesterol (MD -17.08 mg/dL; 95% CI -32.38 to -1.78), highdensity lipoprotein (MD 2.21 mg/dL; 95% CI 0.91 to 3.5), uric acid (MD -0.41 mg/dL; 95% CI -0.80 to -0.01), but non-significant changes were observed in homeostatic model assessment index (MD -2.34; 95% CI: -4.83 to 0.14), and fasting plasma insulin (MD -4.03 µU/mL; 95% CI: -8.88 to 0.82). No publication bias was detected.
conclusionsSacubitril/valsartan provides modest but significant improvements across multiple glycemic and lipid parameters, supporting a favorable metabolic action in clinical practice in patients with heart failure.
trial registrationThe study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD420251057875).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.