ArticleBMC musculoskeletal disorders2026
Long-term functional and clinical outcomes of intraarticular double-cross-linked high molecular weight hyaluronic acid (Crespine Gel Plus) injection in knee osteoarthritis: a one year prospective study.
Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736781 (Long-term Functional Outcome of a Single Hyaluronic Acid Injection in Patients With Knee Osteoarthritis), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Functional Outcome of a Single Hyaluronic Acid Injection in Patients With Knee Osteoarthritis
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnee osteoarthritis (OA) causes substantial pain and disability. Double cross-linked, high-molecular-weight hyaluronic acid (HMWHA; Crespine Gel Plus) may extend symptom relief beyond the typical 3 to 6 month horizon, but robust 12-month data remain limited. This study aimed to evaluate short- and long-term outcomes over 12 months following a single Crespine Gel Plus injection in routine care.
methodsProspective single arm cohort at a Malaysian Hospital from June 2023 to June 2025. Adults with radiographically confirmed knee OA (Kellgren–Lawrence [KL] grades I–III, or IV if declining surgery) received a single 2 mL intra-articular injection. Outcomes were KOOS4 (primary; 0–100, higher = better) and VAS pain (0–10; higher worst) along with KOOS4 Subscales. Assessments were at baseline, 3 months, and 12 months. Linear mixed-effects models (participant random intercepts; REML; Satterthwaite dfs) adjusted for age, gender, BMI, and KL grade.
resultsOf 111 participants (mean age 65.1 ± 7.8; 66.6% female; BMI 28.2 ± 4.9 kg/m2), 107 (96.4%) completed 3-month follow up and 92 (82.9%) completed 12-month follow up. Adjusted KOOS4 improved by 8.59 points (95% CI 5.48–11.69) at 3 months and 8.78 (5.51–12.05) at 12 months (both p < 0.001), exceeding customary minimal clinically important differences (MCIDs). VAS decreased by 1.68 points (-2.03 to -1.33) at 3 months and 1.64 points (-2.01 to -1.27) at 12 months (both p < 0.001). KOOS Pain, Symptoms, ADL, and QoL improved at at 3 and 12 months, with small, non-significant changes between 3 and 12 months. Higher BMI predicted worse adjusted KOOS outcomes; age and KL grade were not significant predictors. No major adverse events occurred.
conclusionA single injection Crespine Gel Plus was associated with clinically meaningful improvements in pain and function that emerged by 3 months and were maintained to 12 months, with a favourable tolerability profile.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.