Evidence map›Paper›PMID 41664263›Full record

SynthesisJournal of occupational and environmental medicine2026

Jet Fuel Effects on Hepatic and Renal Health: A Fit-for-Purpose Systematic Literature Review.

Manasi Kotulkar, Lisa M Prince, Anastasia N Freedman, Anna Kolanowski, Mary Lundin, Hannah M Starnes, Samantha J Goodman, Janielle Vidal, Hannah Buerk, Sagi Enicole A Gillera and 12 more

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of occupational and environmental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Manasi KotulkarFrom the ICF, Reston, Virginia (M.K., L.M.P., A.N.F., A.K., M.L., H.M.S., S.J.G., J.V., H.B., S.E.A.G., N.N.T., R.P.R., L.E.P., S.M.H., L.J.F., J.L.N.S., K.R.W., S.J.S., S.E.E., C.E.H.); and Exposure Science Program, Health Outcomes Military Exposures, Department of Veterans Affairs, Washington, DC (J.G.B., T.D.V.H.).ORCID 0000-0002-3277-5463
Anastasia N FreedmanORCID 0000-0001-6107-4642
Samantha J GoodmanORCID 0000-0003-4828-0964
Sagi Enicole A GilleraORCID 0000-0002-8064-1697
Léa Jean-FrançoisORCID 0009-0001-1405-0290
Jenna L N SprowlesORCID 0000-0001-6198-8057
Kate R WeinbergerORCID 0000-0001-6001-0081
Justin G BergeronORCID 0009-0009-2665-8277
Terra D Vincent-HallORCID 0009-0000-4218-4010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to assess the possible hepatic and renal health effects of jet fuels used by the US military.

methodsA systematic literature review utilizing epidemiologic, animal toxicological, and mechanistic studies was conducted to evaluate hepatic and renal health effects following jet fuel exposure.

resultsEpidemiologic evidence for renal and hepatic outcomes was indeterminate, primarily due to the limited number and quality of human studies. Animal toxicological studies provided moderate evidence that jet fuel exposure impacts the renal system, while there was slight evidence for hepatic effects.

conclusionsEvidence suggests that exposure to jet fuels may cause nephrotoxicity and hepatotoxicity in humans. However, uncertainty remains due to the inconsistent direction of effects, the limited number of studies examining specific health outcomes, and the few published human studies available for review.

Indexed as

HydrocarbonsKidneyKidney DiseasesLiverOccupational ExposureAnimalsHumansMilitary PersonnelUnited StatesHydrocarbonsJP8 aviation fuelhepatichepatotoxicityjet fuelskidneylivernephrotoxicityrenalsystematic review

Identifiers

PMID41664263
PMCPMC12928806

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.