Evidence map›Paper›PMID 41664291›Full record

SynthesisJournal of occupational and environmental medicine2026

The Effects of Jet Fuel Exposure on the Innate and Adaptive Immune Systems: A Fit-for-Purpose Systematic Literature Review.

Emma C Bowers, Janielle Vidal, Anastasia N Freedman, Elizabeth M Martin, Nyssa N Tucker, Anthony K Hannani, Anna Kolanowski, Hannah Buerk, Samantha J Goodman, Alexander J Lindahl and 5 more

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of occupational and environmental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emma C BowersFrom ICF, Reston, Virginia (E.C.B., J.V., A.N.F., E.M.M., N.N.T., A.K.H., A.K., H.B., S.J.G., A.J.L., S.J.S., S.E.E., C.E.H.); and Exposure Science Program, Health Outcomes Military Exposures, Department of Veterans Affairs, Washington, DC (T.D.V.H.).ORCID 0000-0002-2009-2489
Anastasia N FreedmanORCID 0000-0001-6107-4642
Elizabeth M MartinORCID 0000-0001-8428-7034
Anthony K HannaniORCID 0009-0001-4543-3788
Samantha J GoodmanORCID 0000-0003-4828-0964
Alexander J LindahlORCID 0000-0002-7350-5929
Jenna L N SprowlesORCID 0000-0001-6198-8057
Terra D Vincent-HallORCID 0009-0000-4218-4010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to understand the immune health effects of jet fuels used by the US military.

methodsA systematic review of epidemiologic, animal toxicological, and mechanistic studies was conducted to assess evidence on immune effects following jet fuel exposure. Data were synthesized to evaluate evidence for specific immune health outcomes.

resultsAnimal toxicological studies provided moderate evidence that jet fuel exposure causes immune suppression and adversely impacts the immune system by altering immune organ weight, cellularity, and cellular function. Adverse changes were observed predominantly within the adaptive immune system, particularly T cells. There was indeterminate epidemiologic evidence that jet fuel exposure caused immune effects in humans.

conclusionsEvidence indicates that jet fuel exposure is likely to produce adverse immune effects, particularly in the adaptive immune system. Critical data gaps remain regarding impacts on host resistance, neoplastic disease, and autoimmune disorders.

Indexed as

Adaptive ImmunityHydrocarbonsImmunity, InnateOccupational ExposureAnimalsHumansImmune SystemHydrocarbonsadaptive immune systemimmune systemimmunosuppressioninnate immune systemjet fueljet propellant

Identifiers

PMID41664291
PMCPMC12928785

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.