Evidence map›Paper›PMID 41664435›Full record

ArticleEuropean journal of neurology2026

Prevalence and Impact of Probable REM Sleep Behavior Disorder in Essential Tremor: A Multicenter Cross-Sectional Study.

Yuzheng Wang, Mingqiang Li, Runcheng He, Xiaomei Duan, Liang Jin, Dong Chang, JuanWan, Meiqi Jiang, Jiayi Wu, Mingshan Cai and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuzheng WangDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0009-0001-4113-1141
Mingqiang LiDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0009-0000-4127-847X
Runcheng HeDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaomei DuanDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Liang JinDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Dong ChangDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
JuanWanDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Meiqi JiangDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jiayi WuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Mingshan CaiDepartment of Neurology, The Nanhua Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Sheng ZengDepartment of Geriatric Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mei YuanDepartment of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Heng WuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Chunyu WangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0009-0004-8466-5794
Guohua ZhaoDepartment of Neurology, The Fourth Affiliated Hospital, International Institutes of Medicine, School of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Qiying SunDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-2031-8345
Beisha TangDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0003-2120-1576
China Essential Tremor Alliance

Funding

National Natural Sciences Foundation of China 82171256National Natural Sciences Foundation of China 82571629National Natural Sciences Foundation of China U20A20355University of South China Clinical Research 4310 Program 20214310NHYCG08University of South China Clinical Research 4310 Program 20224310NHYCG08
6 · The paper itself

Abstract

objectivesTo investigate the prevalence of probable REM sleep behavior disorder (pRBD) in essential tremor (ET), identify associated risk factors, and evaluate its effects on motor and non-motor symptoms.

methodsClinical data were collected from 1297 ET patients across multicenter. pRBD was assessed using the RBD Questionnaire-Hong Kong (RBDQ-HK). Risk factors associated with pRBD were identified through multivariable logistic regression. Furthermore, a meta-analysis was conducted to synthesize existing estimates of pRBD/RBD prevalence in ET.

resultsIn this study, pRBD was identified in 11.6% of ET patients. Meta-analysis yielded pooled prevalence estimates of 16% for pRBD (ES = 0.16, 95% CI [0.10-0.21]) and 14% for RBD (ES = 0.14, 95% CI [0.07-0.21]). ET patients with pRBD were older (59.89 ± 13.99 vs. 54.63 ± 16.59 years, p < 0.001) and had a later tremor onset (47.55 ± 15.98 vs. 43.15 ± 17.62 years, p = 0.007) compared with those without pRBD. ET-pRBD patients also exhibited a higher frequency of midline tremor (54.67% vs. 43.93%, p = 0.003), rest tremor (27.33% vs. 16.04%, p = 0.001), and elevated Non-Motor Symptom Scale (NMSS) scores (20.30 ± 18.50 vs. 10.43 ± 12.42, p < 0.001). Multivariable logistic regression identified lower educational attainment (OR = 0.93, p = 0.002) and higher NMSS scores (OR = 1.03, p < 0.001) as independent risk factors.

conclusionspRBD is prevalent in ET and independently associated with lower education and increased non-motor symptom burden. Recognition of pRBD may help identify an ET subgroup with distinctive clinical features.

Indexed as

Essential TremorREM Sleep Behavior DisorderAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk Factorsessential tremormeta‐analysisprevalencerapid eye movement sleep behavior disorderrisk factors

Identifiers

PMID41664435
PMCPMC12886745

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.