Evidence map›Paper›PMID 41664441›Full record

ArticleJournal of clinical periodontology2026

Association of Edentulism With Subsequent Biological Age: A Cohort Study.

Yusuke Matsuyama, Sakura Kiuchi, Jun Aida

Abstract read
In one paragraph

Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yusuke MatsuyamaDepartment of Dental Public Health, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0002-6114-5604
Sakura KiuchiDepartment of Dental Public Health, Institute of Science Tokyo, Tokyo, Japan.
Jun AidaDepartment of Dental Public Health, Institute of Science Tokyo, Tokyo, Japan.

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
Integrting Information About Aging SurveysR01AG030153 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, Alden L. Gross · 2007 to 2026
$41.7M
Mega Meta Data Set of the Health and Retirement Surveys Around the WorldRC2AG036619 · NIA · RAND CORPORATION · PI KAPTEYN, ARIE · 2009 to 2010
$2.0M
Archiving & Creating User Friendly Data: the Longitudinal Aging Survey in IndiaR03AG043052 · NIA · RAND CORPORATION · PI LEE, JINKOOK · 2012 to 2012
$95k
Japan Society for the Promotion of Science 24K02658National Institute for Health and Care Research (NIHR)NIA NIH HHS R01AG017644NIA NIH HHS R01AG030153NIA NIH HHS R03AG043052NIA NIH HHS RC2AG036619
6 · The paper itself

Abstract

backgroundBiological ageing is characterised by a gradual decline in physiological functions, resulting in increased susceptibility to diseases and mortality. We investigated the relationship between edentulism and biological ageing among adults in England.

methodsData were drawn from participants in the English Longitudinal Study of Ageing who completed three consecutive biennial waves (waves 2-3-4 or 4-5-6), yielding 1889 individuals providing 2390 three-wave panel observations (mean age at baseline 68.1; men 47.7%). Edentulism was assessed in waves 3 and 5. Biological ageing was estimated using the Klemera and Doubal method, integrating multiple biomarkers assessed in waves 2, 4 and 6. Linear regression with clustered standard errors was employed to evaluate the association between edentulism and biological age in the subsequent wave (i.e., 2 years after the assessment of edentulism). Models were adjusted for pre-exposure confounders, including biological age, gender, socioeconomic status, existing health conditions and functional limitation assessed in the prior wave (i.e., 2 years before the assessment of edentulism).

resultsParticipants with edentulism exhibited a 5.8-year greater biological age than those with some remaining teeth in the subsequent waves. After adjusting for confounding variables, edentulism was associated with a 0.82-year greater biological age than those with some remaining teeth (95% confidence interval: 0.40-1.24) in the subsequent waves.

conclusionEdentulism was longitudinally associated with a greater biological age. Strategies that incorporate oral health promotion, particularly the prevention of tooth loss, may contribute to healthy ageing.

Indexed as

AgingMouth, EdentulousAgedCohort StudiesEnglandFemaleHumansLongitudinal StudiesMaleMiddle Agedbiostatisticsdental public healthedentulousepidemiologygerontology

Identifiers

PMID41664441
PMCPMC13086547

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.