Observational studyScience progress
Temperature trajectory in septic patients with hypothermia: When the ice begins to melt-A retrospective cohort study.
Observational study in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveSepsis is a heterogeneous syndrome, and identifying its subphenotypes may enhance clinical management. Hypothermia may be an indicator of poor outcomes in septic patients.MethodsThis retrospective observational study included septic patients with hypothermia identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Group-based trajectory modeling was used to identify temperature trajectory subphenotypes. Cox proportional hazards model, inverse probability of treatment weighting, and doubly robust estimation were used to explore the association between the subphenotypes and clinical outcomes.ResultsA total of 1816 patients were included in the analysis, and their 48-hour temperature trajectories were categorized into three classes. The Cox proportional hazard model revealed that compared with class 2, class 1 was associated with increased 7-day mortality (HR 1.90; 95% CI 1.18-3.07;
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