SynthesisBone & joint research2026
Antiosteoporotic treatment promotes tendon-to-bone healing after rotator cuff repair : a systematic review of animal studies.
Synthesis in Bone & joint research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Overview of Osteoporosis and Rotator Cuff Disease.Biomedicines · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: To determine whether antiosteoporosis treatment promotes tendon-to-bone healing after rotator cuff repair (RCR) in animal models. Methods: This systematic review adhered to the PRISMA guidelines and was registered on PROSPERO (registration number: CRD42024519176). PubMed, Web of Science, Embase, and the Cochrane Library databases were searched from the inception to 13 January 2025. All the studies that used antiosteoporotic treatment as an intervention after RCR in animal models were included. The methodological quality was assessed using SYRCLE's risk of bias tools. The following data were extracted: author's name, animal characteristics, injury model, intervention measures, and main outcomes. Two reviewers independently conducted the literature search, data extraction, and quality assessment. Results: A total of 19 studies were included. Bisphosphonates (n = 5), parathyroid hormone (PTH) (n = 8), growth factors (n = 3), raloxifene (n = 1), denosumab (n = 1), and sclerostin antibody (n = 1) were applied as interventions. Overall, 15 studies used an animal model of rats, along with two in rabbits and two in sheep. Histology, imaging, biomechanics, muscle quality, gene expression, and serum biochemistry were evaluated as outcomes. Out of 16 studies that evaluated histological outcomes, 12 reported that antiosteoporosis treatment significantly promoted histological healing at the repair site. All ten studies which assessed bone microstructure showed that this was significantly improved. Of the 15 animal studies, 13 indicated that the biomechanical properties were enhanced following RCR when using antiosteoporotic treatment. All three studies reported that muscle quality was significantly improved, and all five studies found that the gene expression and serum biochemistry associated with osteogenesis were significantly elevated. Conclusion: The current study had high heterogeneity and major methodological flaws in the included studies, which limit the scope of these conclusions. However, based on histological, radiological, biomechanical, muscle quality, and serum biochemical analyses, antiosteoporosis treatments may be considered to enhance tendon-to-bone healing after RCR.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.