Evidence mapPaperPMID 41665359Full record

ReviewmBio2026

The vaginal microbiome, papillomavirus infection, and cervical cancer: established associations in search of model systems and mechanistic answers.

Gianna V Passarelli, Sonia N Whang, Nicole M Gilbert, Jiafen Hu

Abstract readReview
In one paragraph

Review in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gianna V Passarelli *The Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA.
Sonia N Whang *Department of Pediatrics, Division of Infectious Diseases, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0009-0000-1744-0801
Nicole M GilbertDepartment of Pediatrics, Division of Infectious Diseases, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-4830-3257
Jiafen HuThe Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0001-8700-9937

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-risk human papillomavirus (HPV) infection is the causative factor for approximately 5% of all human cancers and the leading cause of cervical cancer. High-risk HPV-associated cervical cancer still claims more than 340,000 women's lives globally each year despite the availability of prophylactic HPV vaccines. Currently, there is no medical treatment for HPV infections and associated lesions except invasive surgical procedures. For more than a decade, numerous studies have demonstrated a correlation between certain community state types (CSTs) of the vaginal microbiome and HPV-associated infection and cancer. This review aims to provide a general overview of the most recent studies on this topic, focusing primarily on clinical data linking a

Indexed as

Human Papillomavirus VirusesMicrobiotaPapillomavirus InfectionsUterine Cervical NeoplasmsVaginaAnimalsDisease Models, AnimalDysbiosisFemaleHumansMiceVaginosis, Bacterialbacterial vaginosis (BV)cervical cancercervical intraepithelial neoplasia (CIN)cervical pathogenesisco-infectiondysbiosishuman papillomavirus (HPV)lower genital infectionmouse modelthe mouse papillomavirus (MmuPV1)vaginal microbiome

Identifiers

PMID41665359
PMCPMC12977512

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.