Evidence map›Paper›PMID 41665639›Full record

ArticleJournal of natural products2026

Mixtures Biotransformation: Multilayer Molecular Networking of Kratom Liver Metabolites.

William J Crandall, Jaclyn Weinberg, Ken Liu, Choon-Myung Lee, Grant Singer, Edward T Morgan, Dean P Jones, Cassandra L Quave

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William J CrandallMolecular and Systems Pharmacology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-2537-2033
Jaclyn WeinbergMolecular and Systems Pharmacology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.
Ken LiuDepartment of Chemistry, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.
Choon-Myung LeeDepartment of Medicine: Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.
Grant SingerMolecular and Systems Pharmacology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.
Edward T MorganDepartment of Pharmacology & Chemical Biology Professor Emeritus, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.
Dean P JonesDepartment of Medicine: Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.
Cassandra L QuaveDepartment of Dermatology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0001-9615-7886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolites generated from therapeutic drugs can exhibit diverse pharmacological effects, making knowledge of metabolites important to understand the overall mechanisms of therapeutic action. Methods to study the metabolism of single or simple mixtures of bioactive agents are often insufficient to address the chemical diversity of natural product mixtures. Molecular network analysis has emerged as a powerful approach to gain an understanding of complex chemical mixtures. In the present study, we used

Indexed as

LiverMitragynaBiotransformationChromatography, LiquidHumansLiquid Chromatography-Mass SpectrometryMolecular StructurePlant LeavesPlants, Medicinal

Identifiers

PMID41665639
PMCPMC12954754

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.