Evidence map›Paper›PMID 41665748›Full record

ArticleBulletin of experimental biology and medicine2025

Correction of Post-Traumatic Neurological Deficits Using an Argon-Containing Gas Mixture in a Rat Model of Open Traumatic Brain Injury.

E A Boeva, V V Antonova, R A Cherpakov, M A Lyubomydrov, Z I Tsokolaeva, M E Ivanov, A N Kuzovlev, O A Grebenchikov

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E A BoevaV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia. eboeva@fnkcrr.ru.
V V AntonovaV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
R A CherpakovV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
M A LyubomydrovV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Z I TsokolaevaV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
M E IvanovV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
A N KuzovlevV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
O A GrebenchikovV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of three sessions of 2-h inhalation of an argon-oxygen mixture following open craniocerebral trauma on neurological status, functional outcomes, and MRI results was evaluated in rats. Statistically significant differences were observed between the control (trauma only) and experimental group (trauma + argon-oxygen inhalation) on day 14 in limb-placing test scores, as well as in both lesion volume and hippocampal volume. The experimental group exhibited a more pronounced improvement in neurological function on days 7-14. These findings indicate that the argon-oxygen mixture exerts a significant neuroprotective effect, reduces the extent of brain injury, and promotes recovery of motor function. Notably, to achieve maximal therapeutic benefit, argon-oxygen inhalation should likely be administered not only immediately after injury but also during the subacute phase.

Indexed as

ArgonBrain Injuries, TraumaticNeuroprotective AgentsAdministration, InhalationAnimalsDisease Models, AnimalHippocampusMagnetic Resonance ImagingMaleRatsRecovery of FunctionArgonNeuroprotective Agentsargonhippocampuslesion focusneuroprotective propertiestraumatic brain injury

Identifiers

PMID41665748

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.