ArticleInsights into imaging2026
Clinical feasibility test of 60 kVp double-low-dose coronary CT angiography with a deep learning reconstruction algorithm.
Article in Insights into imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo test the feasibility of 60 kVp double-low-dose coronary CT angiography (CCTA) with a deep learning reconstruction (DLR) algorithm. MATERIALS AND
methodsEighty-nine patients (44 females, 59.9 ± 13.2 years, 23.1 ± 3.3 kg/m
resultsDouble-low-dose CCTA achieved a significant reduction in both radiation dose (0.60 ± 0.12 mSv vs 4.43 ± 1.42 mSv) and contrast volume compared to routine-dose CCTA. For the per-segment level, LD-DLR showed significantly higher specificity (0.99 vs 0.94), positive predictive value (0.91 vs 0.68), and accuracy (0.98 vs 0.94) for ≥ 50% coronary stenosis compared to LD-HIR. The area under the curve of LD-DLR was significantly higher than LD-HIR for ≥ 50% stenosis at per-segment (0.94 vs 0.92), per-vessel (0.92 vs 0.89), and per-patient (0.92 vs 0.85) levels; and for CT-FFR ≤ 0.80 at per-vessel (0.94 vs 0.74), LAD-vessel (0.94 vs 0.71), and LCX-vessel (0.99 vs 0.67) levels. The IQS, SNR, and CNR of LD-DLR were not inferior to those of RD-HIR in all segments.
conclusionsThe 60 kVp double-low-dose CCTA with DLR can significantly reduce radiation dose and simultaneously maintain the high consistency of coronary stenosis and CT-FFR assessments with routine-dose CCTA. CRITICAL RELEVANCE STATEMENT: The 60 kVp double-low-dose CCTA protocol is feasible with a novel DLR algorithm without compromising the performance of coronary stenosis and CT-FFR assessments. KEY POINTS: Is a 60 kVp double-low-dose CCTA protocol with a DLR algorithm feasible for routine clinical application? The 60 kVp CCTA protocol with the DLR algorithm reduced radiation dose by 86.5% and contrast dose by 36.4%. The 60 kVp CCTA with DLR achieved high consistency of coronary stenosis and CT-FFR values with the routine-dose 100 kVp CCTA.
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