Evidence map›Paper›PMID 41665793›Full record

ArticleActa neuropathologica2026

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.

Antonio Masone, Anna Grasso, Liliana Comerio, Rosalia Bruno, Giada Lavigna, Ilaria Vanni, Claudia D'Agostino, Christina D Orrù, Byron Caughey, Hermann C Altmeppen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Antonio MasoneLaboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156, Milan, Italy.
Anna GrassoLaboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156, Milan, Italy.
Liliana ComerioLaboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156, Milan, Italy.
Rosalia BrunoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Giada LavignaLaboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156, Milan, Italy.
Ilaria VanniDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Claudia D'AgostinoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Christina D OrrùLaboratory of Neurological Infections and Immunity, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, USA.
Byron CaugheyLaboratory of Neurological Infections and Immunity, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, USA.
Hermann C AltmeppenInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Joaquín CastillaBasque Research and Technology Alliance (BRTA) - CIC BioGUNE & IKERBasque, Bizkaia, Spain.
Giorgio GiacconeNeuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Fabrizio TagliaviniNeuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Michele A Di BariDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Romolo NonnoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy. romolo.nonno@iss.it.
Roberto ChiesaLaboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156, Milan, Italy. roberto.chiesa@marionegri.it.

Funding

Ministero della Salute RF-2016-02362950
6 · The paper itself

Abstract

Genetic prion diseases are caused by mutant prion protein (PrP) misfolding, eventually leading to the formation of PrP

Indexed as

MutationPrion DiseasesPrionsAnimalsArvicolinaeBrainCreutzfeldt-Jakob SyndromeDisease Models, AnimalHumansInsomnia, Fatal FamilialMiceMice, TransgenicPrions

Identifiers

PMID41665793
PMCPMC12890982

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.