Evidence map›Paper›PMID 41665989›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Allosteric coupling between PIP

Jie Xu, Ana Santa-Cruz, Aishwarya Chandrashekar, Takeharu Kawano, R Charles Kissell, Mehreen Zaka, Zhe Zhang, Meng Cui, Diomedes E Logothetis, Leigh D Plant

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. PIPbioRxiv : the preprint server for biology · 2026
    Article
  2. Allosteric coupling between PIPProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie Xu *Department of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0009-0000-5618-496X
Ana Santa-Cruz *Department of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0009-0004-1519-0529
Aishwarya ChandrashekarDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.
Takeharu KawanoDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0009-0001-0488-7249
R Charles KissellDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0000-0002-7792-2471
Mehreen ZakaDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0009-0007-2643-5028
Zhe ZhangJiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.ORCID 0000-0002-8036-698X
Meng CuiDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0000-0002-3895-135X
Diomedes E LogothetisDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0000-0002-0576-884X
Leigh D PlantDepartment of Pharmaceutical Sciences, Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, Bouve College of Health Science, Northeastern University, Boston, MA 02115.ORCID 0000-0002-1622-1655

Funding

SUMO-regulation of ion channels via PIP2R01HL144615 · NHLBI · NORTHEASTERN UNIVERSITY · PI PLANT, LEIGH DANIEL · 2019 to 2022
$1.6M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01 HL059949-27NHLBI NIH HHS R01 HL144615
6 · The paper itself

Abstract

TMEM16A channels conduct Ca

Indexed as

Anoctamin-1CalciumIon Channel GatingPhosphatidylinositol 4,5-DiphosphateAllosteric RegulationAnimalsBinding SitesHumansMolecular Dynamics SimulationNeoplasm ProteinsANO1 protein, humanAnoctamin-1CalciumNeoplasm ProteinsPhosphatidylinositol 4,5-Diphosphateion permeationmolecular dynamicsPIP2TMEM16A

Identifiers

PMID41665989
PMCPMC12912972

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.