Evidence map›Paper›PMID 41666126›Full record

ArticleJournal of Parkinson's disease2026

Pharmacological inhibition of O-GlcNAcase reduces pS129-α-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice.

Jefferey Yue, Bryan Jones, Kim H Tran, Matthew Deen, Viktor Holicek, Wai Hang Cheng, Mateusz Michalik, Sarah Power, Cheryl L Wellington, Neil V Watson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jefferey YueDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0009-0001-6641-1326
Bryan JonesDepartment of Psychology, Simon Fraser University, Burnaby, BC, Canada.
Kim H TranDepartment of Psychology, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0002-3665-7296
Matthew DeenDepartment of Chemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0002-7902-152X
Viktor HolicekDepartment of Chemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0002-1747-3600
Wai Hang ChengDepartment of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-3408-9184
Mateusz MichalikDepartment of Psychology, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0002-6778-1505
Sarah PowerDepartment of Psychology, Simon Fraser University, Burnaby, BC, Canada.
Cheryl L WellingtonDepartment of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7014-039X
Neil V WatsonDepartment of Psychology, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0002-1709-4889
David J VocadloDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0001-6897-5558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundThe aggregation and spread of α-synuclein within brain are associated with the loss of dopaminergic neurons and the formation of Lewy bodies as seen in Parkinson's disease. Blocking the initiation of α-synuclein aggregation, or the spread of such aggregates, may offer disease-modifying approaches to slow disease progression. Previous studies have demonstrated that modification of aggregation prone proteins, including α-synuclein, with O-linked β-

Indexed as

alpha-SynucleinBenzothiazolesbeta-N-AcetylhexosaminidasesEnzyme InhibitorsParkinson DiseaseProtein Aggregation, PathologicalPyransSubstantia NigraAnimalsDisease Models, AnimalHumansMaleMiceMice, TransgenicThiazolesalpha-SynucleinBenzothiazolesbeta-N-AcetylhexosaminidasesEnzyme Inhibitorshexosaminidase CPyransthiamet GThiazolesLewy bodiesmouse modelO-GlcNAcParkinson's diseaseα-Synuclein

Identifiers

PMID41666126
PMCPMC13347582

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.