Evidence map›Paper›PMID 41666325›Full record

ArticleJournal of medicinal chemistry2026

Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome.

Jason Wallach, Sean Cameron, Michael Dybek, Branden Stanley, Christopher Orme, Nour Riad, Pierce Kavanagh, Simon D Brandt, Adam Knapp, James Gamrat and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jason WallachDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-2467-5761
Sean CameronDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Michael DybekDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Branden StanleyDepartment of Chemistry, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Christopher OrmeDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Nour RiadDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Pierce KavanaghDiscipline of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, Saint James's Hospital, Dublin, Ireland D08 W9RT.
Simon D BrandtThe Alexander Shulgin Research Institute, 1483 Shulgin Road, Lafayette, California 94549, United States.
Adam KnappDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
James GamratDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Rebekah Jauhola-StraightDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Adeboye AdejareDepartment of Pharmaceutical Sciences, Philadelphia College of Pharmacy. Saint Joseph's University, 600 South 43rd St., Philadelphia, Pennsylvania 19104, United States.
Alexander J RogierCollege of Pharmacy, Department of Pharmaceutical Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.
Richa TyagiCollege of Pharmacy, Department of Pharmaceutical Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.ORCID 0009-0001-9228-6311
Clinton E CanalCollege of Pharmacy, Department of Pharmaceutical Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.ORCID 0000-0002-7940-933X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diphenidine is a prototypical 1,2-diarylethylamine that functions as an uncompetitive

Indexed as

Fragile X SyndromeOrganoselenium CompoundsAnimalsBioisosterismDrug DiscoveryHumansMaleMiceRatsReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipOrganoselenium CompoundsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41666325
PMCPMC12951560

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.