Evidence map›Paper›PMID 41666864›Full record

ReviewNeurospine2026

Lumbar Disc Herniation Resorption: When and How Does It Occur?

Carla Cunha, Hanzhi Yang, Zorica Buser, Carola Rojas, Marisa Cunha, Paulo Pereira, In Ho Han, Li Jin, Xudong Li, AO Spine Knowledge Forum Degenerative

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurospine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carla Cunhai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Hanzhi YangDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Zorica BuserDepartment of Orthopedic Surgery, NYU Grossman School of Medicine, New York, NY, USA.
Carola RojasDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Marisa CunhaFaculty of Medicine, University of Porto, Porto, Portugal; Department of Neurosurgery, University Hospital São João, Porto, Portugal.
Paulo PereiraFaculty of Medicine, University of Porto, Porto, Portugal; Department of Neurosurgery, University Hospital São João, Porto, Portugal.
In Ho HanDepartment of Neurosurgery, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Li JinDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Xudong LiDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
AO Spine Knowledge Forum Degenerative

Funding

Deciphering Macrophage Phenotype and Function in Disc Herniation and associated Back/leg PainR01AR078888 · NIAMS · UNIVERSITY OF VIRGINIA · PI XUDONG J. LI · 2022 to 2026
$1.8M
Targeting stage specific influxed monocytes to treat acute and chronic back painR01AR085553 · NIAMS · UNIVERSITY OF VIRGINIA · PI Li Jin, XUDONG J. LI · 2025 to 2026
$1.1M
European Regional Development Fund NORTE2030- FEDER-01801000European UnionFCT - Fundação para a Ciência e a Tecnologia 10.54499/CEECIND/ 00184/2017/CP1392/CT0001FCT - Fundação para a Ciência e a Tecnologia COMPETE2030-FEDER-00691600 - Project nº 15806MOBILIsE_Plus projectNIH HHS R01AR078888NIH HHS R01AR085553
6 · The paper itself

Abstract

Low back pain is a leading cause of disability worldwide, with intervertebral disc herniation contributing substantially to its burden. Most patients improve with conservative care, often associated with disc resorption. Although increasingly recognized as a major determinant of recovery, the mechanisms underlying resorption remain poorly understood. Herniated disc tissue induces immune cell infiltration and release of cytokines and proteolytic enzymes, yet standard anti-inflammatory treatments may paradoxically impede this process. Outcomes are also influenced by physical therapy, lifestyle, herniation characteristics, and immunological background, but predictive biomarkers are lacking. This review summarizes the current knowledge gap and explores strategies to harness intrinsic healing for personalized management.

Indexed as

Back painDisc herniationDisc resorptionMacrophagesRadiculopathy

Identifiers

PMID41666864
PMCPMC12890389

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.