Evidence map›Paper›PMID 41666921›Full record

ArticleCell reports. Medicine2026

Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis.

Yunwei Zhang, Yiyu Zhang, Chengli Shen, Jiye Li, Han Wang, Ahmad Hamad, Chunyan Cao, Mohamad El Moheb, Yu Wang, Yujia Xia and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Physical Exercise in Immunotherapy.Sports medicine - open · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yunwei ZhangDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Yiyu ZhangDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Chengli ShenDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Jiye LiDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Han WangDivision of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Ahmad HamadDivision of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Chunyan CaoDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Mohamad El MohebDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Yu WangDivision of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Yujia XiaDivision of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Kaelyn C CumminsDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Joal BeaneDivision of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Aslam EjazDivision of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA; Division of Surgical Oncology, Department of Surgery, University of Illinois Chicago, Chicago, IL 60612, USA.
Hai HuangCenter for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Allan TsungDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: crf9aa@uvahealth.org.
Hongji ZhangDepartment of Surgery, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: jhn5wx@virginia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer mortality is primarily driven by hepatic metastasis, with 50-60% of patients relapsing following liver metastasis resection due to micro-metastases or tumor cell dissemination. Surgery-induced immunologic disturbances contribute to liver recurrence. Exercise modulates immune responses, yet its role in surgical stress-promoted liver metastasis remains unclear. We demonstrate that 4 weeks of preoperative exercise (PEx) limits tumor growth in a murine model of surgical stress-promoted liver metastasis by shifting Kupffer cells toward an anti-tumor phenotype. PEx promotes Kupffer cell cytotoxic cytokines release and enhances CD8

Indexed as

Colorectal NeoplasmsKupffer CellsLiver NeoplasmsAnimalsButyratesCD8-Positive T-LymphocytesCell Line, TumorChemokine CXCL9FemaleHistone Deacetylase 3HumansMaleMiceMice, Inbred C57BLReceptors, CXCR3ButyratesChemokine CXCL9CXCL9 protein, humanCxcl9 protein, mouseCxcr3 protein, mouseHistone Deacetylase 3Receptors, CXCR3preoperative exercise, colorectal liver metastasis, surgical stress, hepatic immune microenvironment, Kupffer cells, CD8+ T cells, butyrate, histone deacetylase 3, CXCL9, CXCR3

Identifiers

PMID41666921
PMCPMC12923984

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.