Evidence map›Paper›PMID 41667148›Full record

ArticlePediatric obesity2026

Endotoxin Markers Are Elevated in Adolescents With Obesity With and Without Metabolic Dysfunction-Associated Steatotic Liver Disease.

Alison M Boone, Alyssa M Bartlett, Jordan A Bays, Youngsil Kim, Zhongxin Yu, Sirish K Palle, Jacob E Friedman, Kevin R Short

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alison M BooneDepartment of Pediatrics, Section of Diabetes & Endocrinology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.ORCID https://orcid.org/0009-0001-2152-0094
Alyssa M BartlettDepartment of Pediatrics, Section of Diabetes & Endocrinology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Jordan A BaysDepartment of Pediatrics, Section of Diabetes & Endocrinology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Youngsil KimDepartment of Pediatrics, Section of Diabetes & Endocrinology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Zhongxin YuDepartment of Pathology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Sirish K PalleDepartment of Pediatrics, Section of Gastroenterology, Hepatology & Nutrition, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Jacob E FriedmanHarold Hamm Diabetes Center, University of Oklahoma Health, Oklahoma City, Oklahoma, USA.
Kevin R ShortDepartment of Pediatrics, Section of Diabetes & Endocrinology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.ORCID https://orcid.org/0000-0001-6704-9587

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TIMOTHY M VANWAGONER · 2013 to 2026
$68.2M
Understanding the metabolic pathology of pediatric obesity and NAFLDR01DK129656 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FRIEDMAN, JACOB E, SHORT, KEVIN R. · 2022 to 2025
$2.2M
NIDDK NIH HHS R01 DK129656NIGMS NIH HHS U54 GM104938NIH HHS R01DK129656NIH HHS U54GM104938Oklahoma Children's Health FoundationPresbyterian Health Foundation
6 · The paper itself

Abstract

backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in paediatric patients. Adult and murine studies have suggested a role for endotoxin from gram-negative bacteria in the development of MASLD, but there is incomplete and conflicting evidence for its role in adolescents. PURPOSE: To determine if adolescents with biopsy-proven MASLD have elevated endotoxin activity and whether endotoxin markers are associated with liver histological features.

methodsSerum endotoxin core antibodies (EndoCab IgG), lipopolysaccharide binding protein (LBP), soluble CD14 (sCD14) and C-reactive protein (CRP) were measured in adolescents with obesity and MASLD (n = 46), and control groups without MASLD with obesity (Ob, n = 28) or normal weight (NW, n = 34).

resultsCompared to the NW group, both the MASLD and Ob groups had higher EndoCab IgG (56%), LBP (33%) and CRP (11-fold), while sCD14 did not differ. LBP and CRP were positively correlated to trunk and total body fat (r = 0.45 and 0.64, respectively), and to one another (r = 0.42), all p < 0.001. None of the endotoxin markers varied between boys and girls, or with liver steatosis grade or fibrosis stage within the MASLD group.

conclusionSerum markers of endotoxin activity and inflammation are increased in adolescents with obesity but are not further increased in patients with mild to moderate MASLD.

Indexed as

EndotoxinsFatty LiverLiverPediatric ObesityAcute-Phase ProteinsAdolescentBiomarkersCarrier ProteinsChildC-Reactive ProteinFemaleHumansLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMaleMembrane GlycoproteinsAcute-Phase ProteinsBiomarkersCarrier ProteinsC-Reactive ProteinEndotoxinsLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMembrane Glycoproteinsfibrosisgut permeabilityinflammationMASHMASLDpaediatricssteatosis

Identifiers

PMID41667148
PMCPMC13382985

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.