ArticleNature communications2026
Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
12 authors.
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Abstract
Gonadotropin-releasing hormone (GnRH) neurons are the final target of a complex network regulating reproduction. The balance between excitatory and inhibitory inputs is essential for rhythmic GnRH secretion, including pulses and surges, yet the underlying mechanisms remain unresolved. Here, using adult animals of both sexes, we test the hypothesis that excitatory kisspeptin and inhibitory neuronal nitric oxide (NO) synthase (nNOS)-derived inputs orchestrate GnRH release within a microcircuit of kisspeptin, nNOS and GnRH neurons (the "KiNG" network). We focus on nNOS neurons of the organum vasculosum of the lamina terminalis (OV) and the median preoptic nucleus (MePO), which interact with kisspeptin and exhibit cycle-dependent kisspeptin receptor (Kiss1r) expression. Using a highly-sensitive NO/cGMP biosensor together with electrophysiological, genetic, chemogenetic and pharmacological approaches we demonstrate that kisspeptin induces NO-dependent cGMP production in the OV/MePO, including in GnRH neurons, which in turn fine-tunes the GnRH/LH response, providing mechanistic insights into how the KiNG network shapes pulse and surge generation.
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