Evidence map›Paper›PMID 41667489›Full record

ArticleNature communications2026

NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis.

Xiaoyue Wu, Jason G Williams, Haoyang Liang, Artiom Gruzdev, Joshua Hartsell, Jack Shpargel, Rabina Mainali, Yi Fang, Ming Ji, Caroline Duval and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Xiaoyue WuMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Jason G WilliamsMass Spectrometry Research and Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Haoyang LiangDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Artiom GruzdevGene Editing and Mouse Model Core Facility, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0002-1698-7159
Joshua HartsellDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 27695, USA.
Jack ShpargelDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 27695, USA.
Rabina MainaliMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Yi FangMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Ming JiMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0009-0008-4763-850X
Caroline DuvalMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Xin XuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0003-2294-0047
Zixin ZhangDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0009-0005-9865-7135
Heather WinterImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Peter PediaditakisMolecular Pathology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Arun R PandiriMolecular Pathology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0003-0963-9073
Marie E MigaudMitchell Cancer Institute, University of South Alabama, Mobile, AL, 36606, USA.ORCID http://orcid.org/0000-0002-9626-2405
Alan K JarmuschImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0002-2228-6308
Huimin YuDivision of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Xiaojing LiuDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 27695, USA.ORCID http://orcid.org/0000-0002-4231-6017
Jian-Liang LiIntegrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0002-6487-081X
Xiaojiang XuDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA. xxu17@tulane.edu.ORCID http://orcid.org/0000-0001-5758-6581
Igor ShatsMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA. igor.shats@nih.gov.ORCID http://orcid.org/0000-0001-6449-5979
Xiaoling LiMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA. lix3@niehs.nih.gov.ORCID http://orcid.org/0000-0001-5920-7784

Funding

Sirtuins and nuclear receptors in aging and age-associated diseasesZ01ES102205 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LI, XIAOLING · 2007 to 2008
$1.6M
Investigating the involvement of small intestine in metformin's effect on hepatic lipid metabolismR35GM150985 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Xiaojing Liu · 2023 to 2026
$1.6M
National Science Foundation (NSF) 1643814NIGMS NIH HHS R35 GM150985Office of Dietary Supplements (ODS) TAS # 075-24-0846U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) Z01 ES102205
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD) is synthesized through both amidated salvage and deamidated pathways. Although NAD-producing enzymes are often overexpressed in cancer cells to meet the high metabolic demands of rapid proliferation and are considered oncogenic, we report that physiological levels of nicotinic acid phosphoribosyl transferase (NAPRT), the first enzyme in the Preiss-Handler arm of the deamidated pathways, suppress tumorigenesis. We show that NAPRT is enriched in gut epithelial cells, where it sustains the NAD pool for an efficient response to stress-induced acute NAD depletion. Consequently, NAPRT deficiency impairs the activity of poly-(ADP-ribose) polymerases and DNA repair, sensitizes mice to chemical-induced colitis and tumorigenesis, as well as to age-associated spontaneous tumor development. Moreover, low NAPRT expression correlates with poor prognosis in several human cancer types. Thus, homeostatic levels of deamidated NAD biosynthesis contribute to tumor suppression, and boosting this pathway may offer a strategy for cancer prevention.

Indexed as

CarcinogenesisColonNADPentosyltransferasesAnimalsColitisDNA RepairHumansMiceMice, Inbred C57BLMice, KnockoutPoly(ADP-ribose) PolymerasesNADnicotinate phosphoribosyltransferasePentosyltransferasesPoly(ADP-ribose) Polymerases

Identifiers

PMID41667489
PMCPMC13490428

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.