Trial reportScientific reports2026
Targeting aggression with prefrontal high-definition transcranial direct current stimulation.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heightened aggression is associated with behavioural and neural deficits in inhibitory control. Transcranial direct current stimulation (tDCS) shows promise in facilitating inhibitory control and reducing aggression. However, the mixed effects and widespread electric fields of tDCS warrant more precise stimulation methods. High-definition tDCS (HD-tDCS) may enhance focality to target the right inferior frontal gyrus (rIFG), a key region in inhibitory control. In a double-blind and sham-controlled study, we investigated behavioral and neural differences between anodal and sham HD-tDCS in a subsequent Taylor Aggression Paradigm (TAP). Anodal HD-tDCS was applied at 1.5 mA for 20 min over the rIFG. Reference electrodes were located at TP8, PZ, FC3, and FP1. 41 healthy male participants were randomly assigned to either anodal (19) or sham (22) HD-tDCS and completed the TAP during functional magnetic resonance imaging. Anodal HD-tDCS did not directly reduce aggression; however, the stimulation weakened the effect of provocation on aggressive behaviour. Imaging results indicated that anodal HD-tDCS was associated with a positive provocation-related increase of bilateral parietal lobule (IPL) activation. Taken together, behavioural and neuroimaging findings suggest that anodal rIFG stimulation may engage the inhibitory control network as reflected in reduced responsiveness to provocation and increased activation during provocation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.