Evidence mapPaperPMID 41667639Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Moderators of treatment response in late-life depression.

David C Steffens, Breno S Diniz, Neha Jain, Jessica Kluewer-D'Amico, Kevin J Manning, Lihong Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David C SteffensDepartment of Psychiatry and Center on Aging (BSD), University of Connecticut School of Medicine, Farmington, CT, USA. steffens@uchc.edu.ORCID http://orcid.org/0000-0001-6626-7398
Breno S DinizDepartment of Psychiatry and Center on Aging (BSD), University of Connecticut School of Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0003-0653-1905
Neha JainDepartment of Psychiatry and Center on Aging (BSD), University of Connecticut School of Medicine, Farmington, CT, USA.
Jessica Kluewer-D'AmicoDepartment of Psychiatry and Center on Aging (BSD), University of Connecticut School of Medicine, Farmington, CT, USA.
Kevin J ManningDepartment of Psychiatry and Center on Aging (BSD), University of Connecticut School of Medicine, Farmington, CT, USA.
Lihong WangDepartment of Psychiatry and Center on Aging (BSD), University of Connecticut School of Medicine, Farmington, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As late-life depression is associated with a high degree of treatment resistance, understanding predictors of outcome may inform management. In this review, we examine a spectrum of factors that may moderate treatment response. These include clinical moderators related to depression presentation and history, social moderators, psychosocial stressors, personality, and cognitive factors. As there has been substantial research on biological predictors of response, we also include a review of neuroimaging moderators, including markers of accelerated brain aging, as well as other peripheral or central biomarkers of response.

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.