Evidence map›Paper›PMID 41667650›Full record

ArticleNpj imaging2026

A single-step radiolabeling strategy for PET, SPECT, and therapeutic radionuclides using nanoparticles as a universal chelator.

Aitor Herraiz, Andrea Rodríguez-San-Pedro, Marta Casquero-Veiga, Unai Cossío, Nuria Arias-Ramos, Lucía Gutiérrez, Eduardo Romero-Sanz, Víctor Manuel Luján-Rodríguez, Carlos Cerón, Marta Oteo and 8 more

Abstract read
In one paragraph

Article in Npj imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Aitor HerraizNanomedicina, Imagen y modelos 3D (NI3D), Instituto de Química Médica (IQM/CSIC), Madrid, Spain.
Andrea Rodríguez-San-PedroNanomedicina, Imagen y modelos 3D (NI3D), Instituto de Química Médica (IQM/CSIC), Madrid, Spain.
Marta Casquero-VeigaCardiovascular Risk Factors and Brain Function Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.
Unai CossíoCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia San Sebastián, Spain.
Nuria Arias-RamosInstitute for Biomedical Research Sols-Morreale (IIBM), CSIC-UAM, Madrid, Spain.
Lucía GutiérrezInstituto de Nanociencia y Materiales de Aragón, INMA (CSIC-Universidad de Zaragoza) and CIBER-BBN, Zaragoza, Spain.
Eduardo Romero-SanzUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Víctor Manuel Luján-RodríguezUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Carlos CerónCardiovascular Risk Factors and Brain Function Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.
Marta OteoUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Ana González-ParedesNanomedicina, Imagen y modelos 3D (NI3D), Instituto de Química Médica (IQM/CSIC), Madrid, Spain.
Pilar López-LarrubiaInstitute for Biomedical Research Sols-Morreale (IIBM), CSIC-UAM, Madrid, Spain.
Rafael T M de RosalesSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Marta Cortes-CanteliCardiovascular Risk Factors and Brain Function Programme, Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.
Miguel A MorcilloUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Jesús Ruiz-CabelloCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Donostia San Sebastián, Spain.
Juan PellicoCIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Fernando HerranzNanomedicina, Imagen y modelos 3D (NI3D), Instituto de Química Médica (IQM/CSIC), Madrid, Spain. fherranz@iqm.csic.es.

Funding

Consejería de Educación, Juventud y Deporte, Comunidad de Madrid S2022/BMD-7333Ministerio de Ciencia e Innovación PDC2022-133493-100
6 · The paper itself

Abstract

Radiopharmaceuticals that combine diagnostic and therapeutic isotopes are at the forefront of novel cancer treatments. A crucial element is the method of attaching radioisotopes to biomolecules using chelator-based techniques that are widely used clinically. Selection from available chelators is essential because this choice influences the physicochemical and biological characteristics of the final radiopharmaceutical. Numerous chelators exist because none fulfill all ideal conditions: rapid and complete binding to radiometals at low concentrations and with metallic impurities, high thermodynamic and kinetic stability in vivo, easy bioconjugation, and, key for this work, achieving these for many radiometals from the growing list of medical isotopes. We demonstrate how nanotechnology may change this. Ten nano-radiotracers were synthesized, incorporating radiometals such as

Identifiers

PMID41667650
PMCPMC12891502

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.