ArticleBMC women's health2026
CIMT as a sensitive indicator of cardiovascular risk in PCOS: a case-control study of sortilin and sclerostin.
Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPolycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk, and subclinical vascular damage can be evaluated using carotid intima-media thickness (CIMT) and arterial stiffness measures such as pulse wave velocity (PWV). Sortilin and sclerostin have been proposed as cardiometabolic biomarkers, but their value in identifying early cardiovascular risk in PCOS remains unclear. To compare serum sortilin and sclerostin levels and subclinical vascular markers (CIMT and PWV) between women with PCOS and controls, and to evaluate whether these biomarkers are independently associated with CIMT.
methodsIn this case-control study, women with PCOS and age-matched controls were assessed for clinical and metabolic variables. Serum sortilin and sclerostin concentrations were measured, and CIMT and PWV were obtained using standardized protocols. Between-group comparisons were performed, and multivariable linear regression models were constructed with CIMT as the dependent variable.
resultsCIMT was significantly higher in women with PCOS compared with controls, whereas PWV did not differ significantly between groups. Circulating sortilin and sclerostin levels were comparable between groups and were not independently associated with CIMT after multivariable adjustment.
conclusionCIMT appears to be a more sensitive marker of early subclinical atherosclerosis in young women with PCOS than circulating sortilin or sclerostin. These biomarkers cannot currently be recommended for early cardiovascular risk assessment in PCOS. Larger, phenotype-stratified and longitudinal studies are needed to clarify their potential prognostic relevance in specific subgroups.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.