Evidence map›Paper›PMID 41668036›Full record

ArticleBMC medical genomics2026

Genetic insights into hepatocellular carcinoma: the role of VDR FokI (rs2228570) and TaqI (rs731236) polymorphisms in Egyptian patients.

Salma Saleh Alrdahe, Doaa Bahaa Eldin Darwish, Aishah E Albalawi, Awatif M E Omran, Nada Mohammed Almasaudi, Afaf M Elsaid, Magdy M Youssef

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Salma Saleh AlrdaheDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia. salrdahe@ut.edu.sa.ORCID http://orcid.org/0000-0002-8243-6275
Doaa Bahaa Eldin DarwishDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.ORCID http://orcid.org/0000-0002-2646-3340
Aishah E AlbalawiDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.ORCID http://orcid.org/0000-0002-7695-8691
Awatif M E OmranDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.ORCID http://orcid.org/0000-0001-7803-3273
Nada Mohammed AlmasaudiDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Afaf M ElsaidGenetic Unit, Children Hospital Mansoura University, Mansoura, Egypt.
Magdy M YoussefBiochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. mmm_youssef@mans.edu.eg.ORCID http://orcid.org/0000-0003-4205-5379

Funding

The Deanship of Scientific Research at University of Tabuk, Tabuk, Saudi Arabia S-1442-0184
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is the most dominant form of cancer. Its development is influenced by environmental exposures, lifestyle factors, and genetic predispositions. Beyond its classical function in skeleton and mineral metabolism, vitamin D also plays critical roles in immune regulation, tissue fibrosis, and tumor progression through interaction with the vitamin D receptor (VDR). This study aimed to investigate whether variants in the VDR gene are associated with HCC risk in an Egyptian cohort.

methodsOne hundred HCC cases were recruited along with 100 age- and sex-matched healthy controls. Genotyping of the VDR FokI (rs2228570) and TaqI (rs731236) polymorphisms was performed by means of ARMS-PCR assay.

resultsThe VDR FokI (rs2228570 f-allele) and TaqI (rs731236 t-allele) were detected at significantly higher frequencies among HCC patients than healthy participants, and both were associated with increased disease risk (p = 0.002 and p = 0.006, respectively).

conclusionThe results indicate that those variants in the VDR FokI and TaqI genes may increase the predisposition to hepatocellular carcinoma among Egyptians.

Indexed as

Carcinoma, HepatocellularGenetic Predisposition to DiseaseLiver NeoplasmsPolymorphism, Single NucleotideReceptors, CalcitriolAdultAllelesCase-Control StudiesEgyptFemaleGene FrequencyHumansMaleMiddle AgedReceptors, CalcitriolVDR protein, humanGenetic variantsHepatocellular carcinomaVDR

Identifiers

PMID41668036
PMCPMC12998322

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.