Evidence map›Paper›PMID 41668681›Full record

ArticleTransfusion2026

An assessment of green plasma: The in vitro hemostatic superiority of a currently discarded blood product.

Samantha C Redden, David J Sun, Yao-Wei W Wang, Elizabeth Hartwell, Jessica C Cardenas, Scott D Olson, Bryan A Cotton

Abstract read
In one paragraph

Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha C ReddenThe Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA.
David J SunThe Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Yao-Wei W WangThe Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Elizabeth HartwellGulf Coast Regional Blood Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-9895-7921
Jessica C CardenasUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Scott D OlsonThe Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Bryan A CottonThe Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-4184-6742

Funding

Trauma Research and Combat Casualty Care Collaborative 175145
6 · The paper itself

Abstract

introductionRecent studies have linked trauma patient outcomes to the plasma donor's sex, with premenopausal females associated with improved survival and lower organ failure. Currently, green-colored plasma (due to oral contraceptive use) is removed from the donor pool. We set out to evaluate the hemostatic potential of green plasma. STUDY DESIGN &

methodsWe obtained 90 units of plasma from our regional blood center: 30 units of visible green plasma and 60 units of standard-color plasma divided between male and female donors. We collected clinical data such as age, sex, ethnicity, and number of pregnancies. We then assessed the hemostatic potential through thrombelastography (TEG), calibrated automated thrombography (CAT), and clotting factor levels.

resultsGreen plasma unit donors were younger than standard-color female and male donor units (median age 27 vs. 58 vs. 54) and had fewer pregnancies than their non-green female counterparts (median 0 vs. 2); (both p < 0.001). All TEG values, as well as CAT lag time, thrombin potential, and peak thrombin were more hypercoagulable in the green plasma group compared to standard-color female and male donor units; all p < 0.05. In addition, the majority of factor levels (including II, VII, IX, X, and fibrinogen) were higher in green donor plasma; all p < 0.05. DISCUSSION: Based on our data, green plasma has superior hemostatic potential without any other aberrant characteristics, possibly justifying the use of green plasma in transfusion medicine. Reintroducing this product will help to expand on the plasma donor pool.

Indexed as

Blood DonorsHemostasisPlasmaAdultBlood Coagulation FactorsBlood DonationColorFemaleHumansMaleMiddle AgedThrombelastographyBlood Coagulation Factors

Identifiers

PMID41668681
PMCPMC13184430

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.