Evidence map›Paper›PMID 41668745›Full record

ReviewFrontiers in immunology2026

Lipoprotein-associated phospholipase A2 (Lp-PLA2): a key hub linking lipid metabolism and immune inflammation.

Dandan Li, Yuanbo Qian, Li Wan, Kaixin Zhang, Lifeng Song, Xianjing Zhang, Xiaorong Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dandan LiAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Yuanbo QianAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Li WanAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Kaixin ZhangAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Lifeng SongAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xianjing ZhangAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xiaorong YangAffiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as phospholipase A2 group VII (PLA2G7), is an enzyme that serves as a critical nexus between lipid metabolism and immune regulation. It exhibits dual and context-dependent functions by hydrolyzing platelet-activating factor (PAF) and oxidized low-density lipoprotein (oxLDL). The degradation of PAF results in the production of Lysoplatelet activating factor (LysoPAF), which attenuates inflammatory signaling. In contrast, the hydrolysis of oxLDL generates lysophosphatidylcholine (LysoPC) and oxidized fatty acids (oxFA), which exacerbate vascular inflammation, promote macrophage M1 polarization, and inhibit CD8

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseInflammationLipid MetabolismAnimalsBiomarkersHumansLipoproteins, LDLPlatelet Activating Factor1-Alkyl-2-acetylglycerophosphocholine EsteraseBiomarkersLipoproteins, LDLoxidized low density lipoproteinPLA2G7 protein, humanPlatelet Activating Factorbiomarkersimmune regulationlipid metabolismLp-PLA2therapeutic targets

Identifiers

PMID41668745
PMCPMC12883742

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.