Evidence map›Paper›PMID 41668804›Full record

ArticleCancer drug resistance (Alhambra, Calif.)2026

Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters.

Jacob S Roth, Hui Guo, Lu Chen, Min Shen, Omotola Gbadegesin, Robert W Robey, Michael M Gottesman, Matthew D Hall

Abstract read
In one paragraph

Article in Cancer drug resistance (Alhambra, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. A modular framework for antibody-drug conjugate biomarkers.Nature reviews. Clinical oncology · 2026
    Review
  2. Antibody-drug conjugate engineering: from design to efficacy and safety.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
  5. Redefining breast cancer: therapeutic opportunities in HER2-low and emerging molecular subtypes.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  6. Payload Diversification Overcomes Resistance and Guides Sequential Antibody-Drug Conjugate Therapy in Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  7. Review
  8. Review
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  13. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jacob S RothNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Hui GuoNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Lu ChenNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Min ShenNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Omotola GbadegesinLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Robert W RobeyLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Michael M GottesmanLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Matthew D HallNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ABCG2ABC transporterantibody-drug conjugatedrug resistanceP-glycoprotein

Identifiers

PMID41668804
PMCPMC12883344

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.