ArticleRegenerative biomaterials2026
ROS-responsive adhesive nanocomposite hydrogel promotes tendon-to-bone healing by modulating the inflammatory microenvironment and pro-differentiation.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- An intelligent tribological hydrogel delivering 9,10-DiOH activates cuproptosis for comprehensive rheumatoid arthritis intervention.Materials today. Bio · 2026Article
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7 authors.
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Abstract
Natural functional regeneration of the tendon-bone interface in rotator cuff repair surgery remains a major challenge and requires the development of innovative therapeutic strategies. Hydrogels with biomechanical adaptability and regenerative microenvironment modulation are promising candidates for treating such injuries. In this study, an ROS-responsive adhesive nanocomposite hydrogel (TPGA@CZB) was developed to enhance tendon-to-bone interface repair by on-demand drug release to modulate the inflammatory microenvironment and promote cell differentiation. The hydrogel consisted of baicalin (Ba)-loaded Cu-Zn bimetallic-organic framework (CZB), N-[tris(hydroxymethyl) methyl] acrylamide (THMA), poly(ethylene glycol) diacrylate (PEGDA) and phenylboronic acid modified methacrylated gelatin (GelMA-CPBA). Owing to its multi-crosslinked structure, TPGA@CZB exhibits excellent adhesive properties (lap shear strength reaching 110.90 ± 15.38 kPa) and mechanical adaptability (compressive strain exceeding 80% and tensile strain of 196.24 ± 3.87%). Additionally, TPGA@CZB demonstrated favorable ROS-responsive release characteristics, with the cumulative release of Ba in H
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