Evidence map›Paper›PMID 41669248›Full record

ArticlePediatric diabetes2026

Is the Current Screening Availability for Early Stages of Type 1 Diabetes in Germany Related to the Population-Based Frequency of Diabetic Ketoacidosis at Clinical Manifestation in Children and Adolescents.

Alexander J Eckert, Joachim Rosenbauer, Clemens Kamrath, Marina Sindichakis, Ansgar Thimm, Martin Holder, Jantje Weiskorn, Daniel P Lorenz, Susanne Gonzalves, Gita Gemulla and 11 more

Abstract readMulticenter Study
In one paragraph

Article in Pediatric diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alexander J EckertInstitute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany, uni-ulm.de.ORCID 0000-0003-1239-3078
Joachim RosenbauerGerman Center for Diabetes Research (DZD), Munich-Neuherberg, Germany, dzd-ev.de.ORCID 0000-0002-6086-2230
Clemens KamrathDepartment of General Pediatrics, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, University of Freiburg, Freiburg, Germany, uni-freiburg.de.
Marina SindichakisHospital for Children and Adolescents, Klinikum Traunstein, Traunstein, Germany.
Ansgar ThimmDepartment of General Pediatrics, Sana-Hospital Remscheid, Remscheid, Germany, sana.de.
Martin HolderDepartment of Pediatric Endocrinology and Diabetology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany, klinikum-stuttgart.de.ORCID 0000-0002-6577-5400
Jantje WeiskornDiabetes Center for Children and Adolescents, Auf der Bult, Hannover, Germany, auf-der-bult.de.
Daniel P LorenzClinic for Child and Adolescent Medicine, Klinikum Frankfurt Höchst, Frankfurt, Germany, klinikumfrankfurt.de.
Susanne GonzalvesDepartment of Pediatrics, Diakonissen-Stiftungs-Krankenhaus, Speyer, Germany, diakonissen.de.
Gita GemullaDepartment of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, tu-dresden.de.
Sven GolembowskiDepartment of Pediatrics, Sana Hospital Lichtenberg, Berlin, Germany, sana.de.
Ute OhlenschlägerPediatrics, Endocrinology and Diabetology, Friedrich-Ebert Krankenhaus Neumünster, Neumünster, Germany, friedrich-ebert-krankenhaus.de.
Dieter HüsemanDepartment of Pediatrics, Werner-Forßmann-Krankenhaus, Eberswalde, Germany.
Katja PalmDivision of Endocrinology, Diabetology and Metabolic Medicine, University Children's Hospital, Magdeburg, Germany, uni-magdeburg.de.
Andreas LemmerDepartment of Pediatrics and Adolescent Medicine, Helios Clinical Center, Erfurt, Germany, helios-kliniken.de.
Valentina LahnChildren's Hospital Hamburg-Altona, Hamburg, Germany.
Antonia MüllerClinic Group Dr. Guth GmbH and Co. KG, Clinical Center Karlsburg, Greifswalder Straße 11, Karlsburg, Germany.
Donald WurmDepartment of Paediatrics, Marienhaus Klinik Neunkirchen, Neunkirchen, Germany, marienhaus-klinikum.de.
Marjatta WütherichChild and adolescent medicine, Klinikum Bremen-Nord, Bremen, Germany.
Reinhard W HollInstitute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany, uni-ulm.de.
DPV-Wiss-Initiative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Is the current screening for early-stage type 1 diabetes (T1D) associated with the rate of diabetic ketoacidosis (DKA) at T1D manifestation at population level? Materials and Methods: Children with T1D manifestation in 2015-2023 in Germany, aged 0.5 to <15 years from the multicenter diabetes registry (DPV) were included and allocated to federal states (FSs) based on their residential postal code. The relative risk (RR) with 95% confidence interval for DKA at manifestation of T1D by FS with vs. without screening, and demographic/context factors was calculated using logistic regression models. Results: 24,408 children (54.3% males) were included with median onset age of 8.8 (quartiles: 5.3; 11.8) years. The RR for DKA was not significantly lower in FS with vs. without screening (RR: 0.96 [0.93-1.03], Conclusions: Until 2023, current regional screening initiatives for early-stage T1D were not associated with lower frequency of DKA at population level, but might be helpful in the future if the coverage can be markedly increased.

Indexed as

Diabetes Mellitus, Type 1Diabetic KetoacidosisMass ScreeningAdolescentChildChild, PreschoolFemaleGermanyHumansInfantMaleRegistriesFr1daimmigrant backgroundpediatricphysician densitypreventionurbanity index

Identifiers

PMID41669248
PMCPMC12884009

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.