ArticleFrontiers in oncology2025
CYP4B1 inhibits lung adenocarcinoma progression via PI3K/AKT/mTOR pathway: mechanistic insights and development of a CYP4B1-related prognostic signature.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lung adenocarcinoma (LUAD) has a poor 5-year survival rate due to delayed diagnosis and drug resistance. Cytochrome P450 4B1 (CYP4B1), a lung-predominant enzyme, is linked to cancer susceptibility, but its role and regulation in LUAD remain unclear. Methods: Multi-omics analyses of public datasets (TCGA_LUAD, GSE series) and clinical specimens assessed CYP4B1 expression. Functional experiments (cell lines, xenografts) explored its effects. Mechanistic studies (Western blot, ChIP) and transcriptional regulation assays (luciferase reporters) were performed. A CYP4B1-related risk score (CRRS) and nomogram were developed via LASSO-Cox regression and validated. Results: CYP4B1 is significantly downregulated in LUAD, correlating with poor patient survival (AUC > 0.78 for diagnostic discrimination between LUAD and normal tissues). Functionally, CYP4B1 inhibits LUAD cell proliferation Conclusion: CYP4B1 functions as a tumor suppressor in LUAD, regulated by NFIA and exerting its effects through PI3K/AKT/mTOR pathway inhibition. The CRRS and nomogram provide potential tools for prognosis assessment and offer guidance for precision therapy in LUAD, pending further translational validation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.