ArticleAdvanced biomedical research2025
Effect of siRNA-mediated LGR5 Inhibition on the Expression of Stemness-related Genes in Triple-negative Breast Cancer Spheroid Model.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Approximately 10%-15% of all breast cancer diagnoses are identified as triple-negative breast cancer (TNBC), a subtype known for its poor prognosis due to chemoresistance. TNBC lacks any receptors or proteins that are overexpressed, thus lacking targeted therapy. The protein Materials and Methods: Multicellular spheroids of the MDA-MB-231 TNBC cell line were prepared. The exosome was extracted from the human adipose mesenchymal stem cells (ADMSCs) and confirmed. Multicellular spheroids were separately transfected with siRNA, EXO-siRNA and, treated with cisplatin alone. Gene expression was studied using qRT-PCR. Results: Our findings revealed that inhibiting Conclusions: In summary, the results indicated that
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