ArticleAdvanced biomedical research2025
Evaluation of Letrozole and Methotrexate in the Management of Ectopic Pregnancy - A Randomized Clinical Trial Study.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Ectopic pregnancy (EP) is one of the critical health conditions worldwide. Letrozole, an aromatase inhibitor that suppresses peripheral conversion of androgens to estrogens, has recently been introduced as a low-cost and minimal side effects treatment for EP. We studied the use of the letrozole for the treatment of EP in comparison with methotrexate. Materials and Methods: This double-blind randomized clinical trial was conducted on 40 women with uncomplicated EP (into two groups of 20). The letrozole group received a daily regimen of 5 mg tablets for a duration of 10 days, while the methotrexate group received treatment via a single intramuscular injection of 50 mg/m Results: The mean of aspartate aminotransferase (AST), alanine aminotransferase (ALT), hemoglobin, and serum creatinine on the first and seventh days of treatment had no significant difference between the two groups ( Conclusion: According to the results of this study, the biochemical and hematological parameters and success treatment rate did not differ significantly between the administration of letrozole and methotrexate. Due to the occurrence of fewer side effects (although insignificant) in the administration of letrozole, it may be possible to introduce this drug as safer and less invasive than methotrexate.
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