Evidence map›Paper›PMID 41669398›Full record

ArticleFrontiers in behavioral neuroscience2025

Characterizing molecular and behavioral changes arising from ROMK potassium channel deficiency in the cerebellum.

Jacopo Agrimi, Aidan J Dunphy, Justin C Zhong, Wenxi Zhang, Naeem Sbaiti, Daniel R Turner, Lucia Bernardele, D Brian Foster, Brian O'Rourke, Nazareno Paolocci and 1 more

Abstract read
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In one paragraph

Article in Frontiers in behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jacopo Agrimi *Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Aidan J Dunphy *Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Justin C Zhong *Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Wenxi ZhangDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Naeem SbaitiDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Daniel R TurnerDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Lucia BernardeleDepartment of Biomedical Sciences, University of Padova, Padua, Italy.
D Brian FosterDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Brian O'RourkeDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Nazareno PaolocciDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Kyriakos N PapanicolaouDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Funding

Retinoid Metabolism in the Adult Heart and Heart FailureR01HL164478 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI D Brian Foster, MAUREEN A KANE · 2023 to 2026
$2.8M
Targeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1M
NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL164478
6 · The paper itself

Abstract

The cerebellum is critically involved in both motor coordination and affective regulation, and growing evidence suggests that cerebellar dysfunction contributes to neuropsychiatric disorders. While much attention has focused on synaptic signaling and calcium homeostasis, the role of potassium channels in cerebellar function remains relatively understudied. Here, we investigated the role of the potassium channel ROMK (renal outer medulla K

Indexed as

anxiety-like behaviorBartter’s syndromecerebellumGFAPgranule cellsKCNJ1motor coordinationpotassium channels

Identifiers

PMID41669398
PMCPMC12883771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.