ArticleQuantitative imaging in medicine and surgery2026
Correlation between fractional flow and magnetic resonance perfusion in patients with intracranial artery stenosis in the anterior circulation.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The value of hemodynamics in intracranial atherosclerotic stenosis (ICAS) patients has not been fully studied. The purpose of this study was to analyze the correlation between fractional flow (FF) and hypoperfusion in patients with ICAS of the anterior circulation, and compare the performance differences between FF and diameter stenosis (DS) in distinguishing hypoperfusion. Methods: This study included patients with anterior circulation artery stenosis. The determination of cerebral perfusion stages and the calculation of perfusion parameters were based on the magnetic resonance imaging (MRI) perfusion images. The patients were divided into a normal perfusion group and a hypoperfusion group (stages I and II). DS and FF values were calculated on the basis of digital subtraction angiography images. Results: We analyzed 58 patients. FF was negatively correlated with relative time to peak (r=-0.41, P=0.002) and relative mean transit time (r=-0.27, P=0.037). In groups with a larger time to maximum tissue residue function, FF had a lower distribution interval. FF was significantly different between normal perfusion patients and hypoperfusion patients (0.71±0.17 Conclusions: There is a correlation between MRI perfusion and FF in patients with anterior circulation ICAS. A low FF may indicate a higher time to maximum tissue residue function and a poorer hypoperfusion stage. FF provides hemodynamic information that is distinct from and complementary to the anatomical assessment of DS. The ability to compute FF intraoperatively could, in the future, provide real-time feedback on physiological improvement following revascularization.
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