Evidence map›Paper›PMID 41669458›Full record

ArticleQuantitative imaging in medicine and surgery2026

Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging.

Liangpeng Wei, Wen Zhang, Jiaming Lu, Dongming Liu, Xin Li, Gaoping Liu, Huiquan Yang, Haoyao Wang, Zhengyang Zhu, Xiang Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liangpeng Wei *Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Wen Zhang *Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jiaming LuDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Dongming LiuDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xin LiDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Gaoping LiuDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Huiquan YangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Haoyao WangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Zhengyang ZhuDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xiang LiDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xin ZhangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Bing BaiCenter for Precision Medicine, Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Bing ZhangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: White matter hyperintensity (WMH) has been reported to be associated with brain structure changes and Alzheimer's disease (AD) pathology in the aging process. This study sought to explore the underlying mechanisms linking cerebrovascular pathology, structural brain changes, and AD pathology in the aging process. Methods: The routine magnetic resonance images of 218 cognitively normal elderly individuals who underwent venous blood sampling were retrospectively collected. The Fazekas score was used to stratify the cohort into mild (Fazekas scores of 0-1, n=113) and severe (Fazekas scores of 2-3, n=105) WMH groups. All the three-dimensional (3D) T Results: The participants with severe WMH were older (P<0.001) and exhibited higher plasma p-Tau 181 (P<0.001) than those in the mild WMH group, but no significant difference in plasma Aβ42 was found (P=0.065). Based on the original 3D T Conclusions: Severe WMH is associated with caudate nucleus enlargement. WMH may partially mediate the association between elevated plasma p-Tau 181 and caudate nucleus enlargement, suggesting a mixed pathology in the aging process of the brain, and highlighting the importance of early vascular risk control.

Indexed as

Agingcaudate nucleusplasma phosphorylated tau 181 (plasma p-Tau 181)white matter hyperintensities (WMHs)

Identifiers

PMID41669458
PMCPMC12883568

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.