Evidence map›Paper›PMID 41669843›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

Association Between Prepregnancy Blood Pressure and Reproductive Outcomes of In Vitro Fertilization.

Yuan Fang, Ze Wang, Yan Li, Xue Shang, Dongling Xu, Linjie Zhao, Yue Niu, Jialin Zou, Dingying Zhao, Gege Ouyang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Yuan Fang *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Ze Wang *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0002-5719-1499
Yan Li *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0003-1813-8115
Xue ShangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Dongling XuDepartment of Cardiology (D.X.), Shandong University, Jinan, China.
Linjie ZhaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Yue NiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0002-1983-9098
Jialin ZouState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Dingying ZhaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0002-2761-098X
Gege OuyangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Huiying XiaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Ning LiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Yunhai YuDepartment of Obstetrics and Gynecology (Y.Y.), Shandong University, Jinan, China.
Yanran LiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Chendan LiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Yue WangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.
Yingying QinState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0002-0319-7799
Heping ZhangDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT (H.Z.).ORCID 0000-0002-0688-4076
Richard S LegroDepartment of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, PA (R.S.L.).ORCID 0000-0001-9927-7584
Daimin WeiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0002-3455-2984
Zi-Jiang ChenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health (Y.F., Z.W., Y. Li, X.S., L.Z., Y.N., J.Z., D.Z., G.O., H.X., N.L., Y. Liu, C.L., Y.W., Y.Q., D.W., Z.-J.C.), Shandong University, Jinan, China.ORCID 0000-0001-6637-6631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe latest updated 2025 and 2017 American College of Cardiology and the American Heart Association guidelines lowered the diagnostic threshold for hypertension to 130/80 mm Hg. Whether the new classification for hypertension has implications for reproductive outcomes remains uncertain.

methodsThis retrospective cohort study was conducted at the Reproductive Medicine Center of Shandong University in China. Women who underwent the initial embryo transfer of their first in vitro fertilization cycle were categorized into the normal blood pressure (BP), elevated BP, stage 1 hypertension, and stage 2 hypertension groups based on BP levels measured just before in vitro fertilization treatment. We examined associations of prepregnancy BP and reproductive outcomes.

resultsThis study included 43 629 women who received in vitro fertilization treatment. The rate of live birth was lower in women with stage 1 and stage 2 hypertensions (46.1% and 41.4%, respectively) compared with women with normal BP (49.2%), with the adjusted relative ratios of 0.97 (95% CI, 0.937-0.996;

conclusionsCompared with normal BP, prepregnancy stage 1 and stage 2 hypertension were associated with a lower rate of live birth after in vitro fertilization treatment and increased risks of pregnancy complications.

Indexed as

Blood PressureFertilization in VitroHypertensionAdultChinaFemaleHumansLive BirthPregnancyPregnancy OutcomeRetrospective Studiesblood pressurehypertensionpregnancyreproductive medicinewomen

Identifiers

PMID41669843
PMCPMC13001900

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.